Intracellular Infection by Invasive Group A Streptococci

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EXCEEDTHE SPACE PROVIDED. This project will define the relationship betweenintracellular invasion andgroup A streptococcal pathogenesis. Experiments willfurther investigate the molecular mechanisms by which streptococci commandeerthe extracellular matrix (ECM)and receptor signaling systems of host colls to reachan intracellular state. Invivo experimentswill investigate the role of intracellular invasion in persistent infection of nasal associatedlymphoid tissue, employing amurine intranasal infection model. Experiments willevaluate whether streptococci preferentially infect this tissue. Wepropose that persistence depends onthe potentialof streptococci to beefficiently ingested by specific cells in this lymphoid tissue. Information gainedfromthis studymay identify newtargets for antibiotic development,and increaseour understanding of the mechanismsby which this pathogen persists in human populations. PERFORMANCE SITE(S) (organization, cily, state) University of Minnesota - Minneapolis MN, USA KEY PERSONNEL. See instructions on Page 11. Use continuation pages as needed to provide the required information in the format shownbelow. Name Organization Role on Project Paul Patrick Cleary University of Minnesota Prin. Investigator Mae-Sun Park University of Minnesota PostdoctoralTrainee !>ai Sudha Purushothaman University of Minnesota PostdoctoralTrainee T'HS 398 (Rev. 4/98) Page 2 BB Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. ========================================Section End===========================================