Streptococcal Inactivator in Human Chemoattractants

人类化学引诱剂中的链球菌灭活剂

• 批准号: 7001294
• 负责人: PAUL Patrick CLEARY
• 金额: $ 25.38万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001294
• 关键词: Streptococcal; Inactivator; Human; Chemoattractants

DESCRIPTION (provided by applicant): This project is an attempt to understand the mechanism by which group A streptococcus modulates host defenses. These streptococci have evolved proteins including the C5a peptidase that destroys C5a, an important early signal that attracts protective phagocytes to infected tissue. The recent discovery that the peptidase is also a fibronectin and cell-binding protein has become a significant new focus. Experiments are planned to evaluate the importance of these activities, relative to peptidase activity in virulence using intranasal and subdermal mouse models of infection. Recognition that penicillin often fails to eliminate group A streptococci from throats of ill children and the recent resurgence of serious complications associated with streptococcal infections, has prompted an intense effort to develop preventive vaccines by industry and NIH. The C5a peptidase is a major focus of vaccine development, increasing the need to learn more about its role in virulence, and its impact on host defenses. New data indicates that the C5a peptide required for successful colonization and persistence of streptococci in nasal associated lymphoid tissue.

描述（由申请人提供）：该项目是一个试图了解的机制，其中组A链霉菌调节主机防御。这些链球菌已经进化出蛋白质，包括破坏C5a的C5a肽酶，C5a是吸引保护性吞噬细胞到感染组织的重要早期信号。最近发现，肽酶也是一种纤维连接蛋白和细胞结合蛋白已成为一个重要的新焦点。 计划使用鼻内和皮下小鼠感染模型，评价这些活性相对于肽酶活性在毒力中的重要性。认识到青霉素往往不能消除A组链球菌从患病儿童的喉咙和最近的严重并发症与链球菌感染的复苏，促使工业界和国家卫生研究院大力开发预防性疫苗。C5a肽酶是疫苗开发的主要焦点，增加了了解其在毒力中的作用及其对宿主防御的影响的需要。新的数据表明，C5a肽是链球菌在鼻相关淋巴组织中成功定植和持久存在所必需的。

项目成果

Complete nucleotide sequence of the streptococcal C5a peptidase gene of Streptococcus pyogenes.

• DOI: 10.1016/s0021-9258(19)39748-0
• 发表时间: 1990-02
• 期刊: The Journal of biological chemistry
• 作者: Chunsheng Chen;P. Cleary

M(+) group a streptococci are phagocytized and killed in whole blood by C5a-activated polymorphonuclear leukocytes.

M( ) a 组链球菌在全血中被 C5a 激活的多形核白细胞吞噬并杀死。

• DOI: 10.1128/iai.70.1.350-359.2002
• 发表时间: 2002
• 期刊: Infection and immunity
• 影响因子: 3.1
• 作者: DeMaster,Eric;Schnitzler,Norbert;Cheng,Qi;Cleary,Patrick
• 通讯作者: Cleary,Patrick

Immune response to group A streptococcal C5a peptidase in children: implications for vaccine development.

• DOI: 10.1086/377700
• 发表时间: 2003-09
• 期刊: The Journal of infectious diseases
• 作者: A. Shet;E. L. Kaplan;Dwight R. Johnson;P. Cleary

Group B streptococci inhibit the chemotactic activity of the fifth component of complement.

B 族链球菌抑制补体第五种成分的趋化活性。

• 发表时间: 1988
• 期刊: Journal of immunology (Baltimore, Md. : 1950)
• 作者: Hill,HR;Bohnsack,JF;Morris,EZ;Augustine,NH;Parker,CJ;Cleary,PP;Wu,JT
• 通讯作者: Wu,JT

Purification and characteristics of the streptococcal chemotactic factor inactivator.

链球菌趋化因子灭活剂的纯化及特性。

• DOI: 10.1128/iai.50.3.757-764.1985
• 发表时间: 1985
• 期刊: Infection and immunity
• 影响因子: 3.1
• 作者: Wexler,DE;Cleary,PP
• 通讯作者: Cleary,PP