Synthesis of well-defined biodegradable polymers and study of their materials properties

明确的可生物降解聚合物的合成及其材料性能的研究

• 批准号: 2530935
• 金额: --
• 依托单位: Durham University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2530935
• 关键词: Synthesis; well; defined; biodegradable; polymers

Poly(vinyl alcohol) (PVA) is an important commodity polymer which is used extensively in the production of adhesives and protective films, and for biomedical applications. PVA is prepared by the alkaline hydrolysis of poly(vinyl acetate) (PVAc), synthesized industrially by radical polymerization. Such methods offer little scope for engineering the molecular characteristics of the resultant polymers, with poor control over molecular weights and dispersity within the population. Here, we will use reversible-deactivation radical polymerization (RDRP) techniques to produce well-defined PVAc/PVA materials, and study their structural and dynamic properties using a range of x-ray and neutron scattering techniques. Deuterated analogues of PVAc and PVA will also be produced via this route, allowing us to study interdiffusion within polymer films by ion and neutron scattering techniques. The influence of chain-end functionality, and the inclusion of other monomer units through (block) copolymerization, will be explored with a view to making new biodegradable materials of higher mechanical strength, improved solubility or enhanced rheological properties, thus expanding the scope of the applications of PVA-based materials.

聚乙烯醇（PVA）是一种重要的商品聚合物，广泛用于生产粘合剂和保护膜，并用于生物医学应用。聚乙烯醇是由聚醋酸乙烯酯（PVAc）的碱性水解制备的，PVAc是通过自由基聚合工业合成的。这样的方法几乎没有提供工程化所得聚合物的分子特征的范围，对分子量和群体内的分散性的控制差。在这里，我们将使用可逆失活自由基聚合（RDRP）技术来生产定义明确的PVAc/PVA材料，并使用一系列的X射线和中子散射技术研究其结构和动态性能。氘代类似物的PVAc和PVA也将通过这条路线，使我们能够研究聚合物薄膜内的离子和中子散射技术的相互扩散。链端官能度的影响，并包括其他单体单元通过（嵌段）共聚，将探讨，以期使新的生物降解材料的更高的机械强度，改善溶解性或增强流变性能，从而扩大PVA基材料的应用范围。