Diffuse Optical Tomography of Osteoarthritis

骨关节炎的漫反射光学断层扫描

• 批准号: 6891945
• 负责人: HUABEI JIANG
• 金额: $ 30.3万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6891945
• 关键词: bioimaging /biomedical imaging; clinical research; computer program /software; computer system design /evaluation; diagnosis design /evaluation; human middle age (35-64); human old age (65+); human subject; image processing; inflammation; musculoskeletal disorder diagnosis; musculoskeletal imaging /visualization /scanning; optical tomography; osteoarthritis; patient oriented research; radiography; synovial membrane; technology /technique development; three dimensional imaging /topography; tomography

DESCRIPTION (provided by applicant): Osteoarthritis (OA), or degenerative joint disease, is the most common form of joint diseases. It is a slowly progressing disease, and a major cause of morbidity in the population over 50, affecting more than 40 million Americans. It also imposes considerable expense on the health care system. While there is currently no cure for this disease, recent studies have shown that the progression of articular damage may be modified by medical or surgical intervention if the disease is detected early. These studies coupled with recent developments in gene therapy have generated substantial demand for noninvasive techniques for detecting early changes in the joints, when intervention is likely to have its greatest effect. X-ray radiography is excellent for imaging hard tissues and has been a routine modality for examining OA, primarily for advanced OA stages. The limitation of x-ray is its incapability for imaging soft tissues in the joints as well as its incapability for obtaining physiological information related to the functioning of OA. Diffuse optical tomography (DOT) is a promising method for detecting changes in cartilage and inflammation process in synovium. It can also provide information about the functioning and progression of OA. However, DOT has limited spatial resolution comparing to x-ray. To overcome this limitation, in this application we propose a combined x-ray/DOT approach so that we can use the x-ray images as structure guidance for DOT reconstruction. We aim to advance 3D DOT imaging of joint tissue co-registered with 3D x-ray tomosynthesis. Our specific aims include (1) investigation of several tomosynthetic reconstruction methods for 3D x-ray imaging, (2) development of algorithms for segmentation of 3D xray images, (3) development of 3D rendering environment, (4) advanced DOT reconstruction methods including automatic adaptive meshing scheme, parallel computing and a higher-order diffusion model, (5) design, construction and testing of a combined digital x-ray/optical imaging system for 3D imaging of joint tissue, (6) evaluation and optimization of this system using tissue phantom experiments, and (7) testing and evaluation of the combined xray/ optical imaging system in human subjects. If successful, the proposed mulfi-modality imaging method will have a major impact on the ability to make an early and appropriate therapeutic intervention, routinely monitor the progression/clinical outcome and assist in evaluating new treatment modalities.

描述(由申请人提供)： 骨关节炎(OA)或退行性关节疾病是最常见的关节疾病形式。它是一种进展缓慢的疾病，也是50岁以上人口发病率的主要原因，影响着4000多万美国人。它还给医疗保健系统带来了相当大的开支。虽然目前还没有治愈这种疾病的方法，但最近的研究表明，如果及早发现这种疾病，可以通过药物或手术干预来改变关节损害的进展。这些研究再加上基因治疗的最新进展，催生了对非侵入性技术的大量需求，以检测关节的早期变化，此时干预可能会产生最大的效果。X射线摄影对于硬组织的成像是非常好的，并且已经成为检查骨性关节炎的常规方法，主要用于晚期骨性关节炎。X射线的局限性在于它不能成像关节内的软组织，也不能获得与骨性关节炎功能相关的生理信息。弥散光学断层扫描(DOT)是一种很有前途的检测关节软骨改变和滑膜炎症过程的方法。它还可以提供有关办公自动化的运作和进展的信息。然而，与X射线相比，DOT的空间分辨率有限。为了克服这一局限性，在本应用中，我们提出了一种X射线/点扫描相结合的方法，以便我们可以使用X射线图像作为点扫描重建的结构指导。我们的目标是推进关节组织的3DDOT成像，并与3DX光断层合成共同配准。我们的具体目标包括：(1)研究用于3D X射线成像的几种断层合成重建方法，(2)开发3D X射线图像分割算法，(3)3D渲染环境的开发，(4)先进的DOT重建方法，包括自动自适应网格划分、并行计算和高阶扩散模型，(5)设计、构建和测试用于关节组织3D成像的数字X射线/光学成像系统，(6)利用组织模型实验对该系统进行评估和优化，以及(7)在人体中测试和评估X射线/光学联合成像系统。如果成功，建议的多模式成像方法将对早期和适当的治疗干预、常规监测进展/临床结果和协助评估新的治疗模式的能力产生重大影响。