The impact of energy restriction on neural stem cell ageing and cognition: Uncovering molecular mechanisms and anti-ageing mimetic drugs

能量限制对神经干细胞衰老和认知的影响：揭示分子机制和抗衰老模拟药物

• 批准号: 2556920
• 金额: --
• 依托单位: King's College London
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2017
• 资助国家: 英国
• 起止时间: 2017 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2556920
• 关键词: impact; energy; restriction; neural; stem

In this project, it is proposed that energy restriction (ER), i.e. intermittent fasting/calorie restriction, may have a role in regulating neural stem cells (NSC) biology and adult hippocampal neurogenesis and thus have an impact on associated cognition. This project aims to investigate the impact of energy restriction on the ageing of neural stem cells, uncover molecular mechanisms behind it and discover anti-ageing mimetic drugs in the context of humans. We hypothesise that ER in ageing humans will lead to enhanced cognition via modulation of neurogenesis. The aim is divided as follows: AIM 1: Validate the efficacy of energy restriction (ER) as cognition-enhancing intervention in humans. AIM 2: Identify the molecular mechanisms by which ER modulates neural stem cell health, neurogenesis and cognition. AIM 3: Uncover anti-ageing/cognition-enhancing mimetic drugs.

在这个项目中，有人提出，能量限制（ER），即间歇性禁食/热量限制，可能在调节神经干细胞（NSC）生物学和成年海马神经发生中发挥作用，从而对相关认知产生影响。该项目旨在研究能量限制对神经干细胞衰老的影响，揭示其背后的分子机制，并发现人类背景下的抗衰老模拟药物。我们假设，老年人的ER将通过调节神经发生来增强认知能力。 目的分为如下：目的1：验证能量限制（ER）作为人类认知增强干预的有效性。目的2：确定ER调节神经干细胞健康、神经发生和认知的分子机制。目的3：发现抗衰老/增强认知的模拟药物。