Stress-induced alterations in amygdala-LC interactions

压力引起的杏仁核-LC 相互作用的改变

基本信息

  • 批准号:
    6919221
  • 负责人:
  • 金额:
    $ 32.85万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-04-01 至 2008-03-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Stress is known to be a factor in the etiology or exacerbation of psychiatric disorders, and plays an important role in reinstatement of drug-taking behavior. This proposal will use primarily electrophysiological recordings in anesthetized rats to examine the effects of acute and chronic stress on the regulation of the locus coeruleus (LC) by the amygdalar complex. Norepinephrine and corticotropin releasing hormone have been identified as central factors in the response to stress. In particular, the noradrenergic neurons of the LC are known to have a major role in central mediation of stress responses. These neurons are driven by a number of afferent influences. One set of afferents that appears to have a primary role in stress as it relates to psychiatric disorders and relapse to drug abuse are the projections that involve the amygdala. We propose to examine amygdalar regulation of LC neuron activity, and how this system is modified by acute and chronic stress. Our central hypothesis is that chronic stress causes a sensitization of LC neuron responsivity via its effects on amygdalofugal pathways. This will be done along four specific aims: 1) to examine the physiology of projection systems connecting the basolateral amygdala complex with the LC, 2) to examine the response of this system to acute stressors (footshock), and how these responses are modified following chronic cold exposure, 3) to evaluate the nature of the change in LC neuron responsivity following chronic stress, and 4) to determine whether the alteration in LC responsivity following chronic stress can be altered by selective interruption of these amygdalar efferents. We will use primarily in vivo single unit and intracellular recording methods to examine systems-level interactions, with in vitro recordings used to measure persistent changes in LC neuronal activity and to address specific pathway-related questions as they arise. We will independently verify the behavioral effects of chronic cold exposure by measuring acoustic startle, a response that is sensitive to manipulations of the central amygdala and forebrain NE systems. We hope that a better understanding of amygdalar-coerulear systems will lead to insights into how stress-induced pathophysiology in these pathways can, in part, mediate some of the behavioral symptoms of psychiatric disease and drug-abuse disorders.
描述(由申请人提供):众所周知,压力是精神疾病的病因或恶化的一个因素,并且在恢复吸毒行为方面发挥着重要作用。该提案将主要使用麻醉大鼠的电生理记录来检查急性和慢性应激对杏仁核复合体对蓝斑(LC)调节的影响。去甲肾上腺素和促肾上腺皮质激素释放激素已被确定为应激反应的核心因素。特别是,已知 LC 的去甲肾上腺素能神经元在应激反应的中枢调节中具有重要作用。这些神经元由许多传入影响驱动。一组传入神经似乎在压力中起主要作用,因为它与精神疾病和药物滥用复发有关,这些传入神经是涉及杏仁核的投射。我们建议检查杏仁核对 LC 神经元活动的调节,以及该系统如何被急性和慢性应激改变。我们的中心假设是,慢性压力通过影响杏仁核通路,导致 LC 神经元反应性敏感。这将沿着四个具体目标进行:1)检查连接基底外侧杏仁核复合体与 LC 的投射系统的生理学,2)检查该系统对急性应激源(足部电击)的反应,以及这些反应在慢性寒冷暴露后如何改变,3)评估慢性压力后 LC 神经元反应性变化的性质,4)确定慢性压力后 LC 反应性的变化是否可以改变 通过选择性中断这些杏仁核传出神经来改变。我们将主要使用体内单个单元和细胞内记录方法来检查系统级相互作用,并使用体外记录来测量 LC 神经元活动的持续变化,并解决出现的特定通路相关问题。我们将通过测量声惊吓来独立验证慢性寒冷暴露的行为影响,这是一种对中央杏仁核和前脑 NE 系统的操作敏感的反应。我们希望更好地了解杏仁核-蓝核系统将有助于深入了解这些途径中压力诱导的病理生理学如何在一定程度上介导精神疾病和药物滥用障碍的一些行为症状。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

ANTHONY A GRACE其他文献

ANTHONY A GRACE的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('ANTHONY A GRACE', 18)}}的其他基金

Circuit-based Study of Depression/Anhedonia in Rats
大鼠抑郁/快感缺失的回路研究
  • 批准号:
    8694160
  • 财政年份:
    2014
  • 资助金额:
    $ 32.85万
  • 项目类别:
Circuit-based Study of Depression/Anhedonia in Rats
大鼠抑郁/快感缺失的回路研究
  • 批准号:
    9043194
  • 财政年份:
    2014
  • 资助金额:
    $ 32.85万
  • 项目类别:
Circumventing physiological consequences of drug abuse
规避药物滥用的生理后果
  • 批准号:
    8661742
  • 财政年份:
    2013
  • 资助金额:
    $ 32.85万
  • 项目类别:
Circumventing physiological consequences of drug abuse
规避药物滥用的生理后果
  • 批准号:
    8598969
  • 财政年份:
    2013
  • 资助金额:
    $ 32.85万
  • 项目类别:
In vivo neurocircuitry of DBS response in rodents
啮齿类动物 DBS 反应的体内神经回路
  • 批准号:
    8076854
  • 财政年份:
    2010
  • 资助金额:
    $ 32.85万
  • 项目类别:
INTEGRETIVE INFLUENCES OF THALAMIC/CORTICAL INPUTS--PREFRONTAL CORTICAL FUNCTION
丘脑/皮质输入的整体影响——前额皮质功能
  • 批准号:
    7553450
  • 财政年份:
    2007
  • 资助金额:
    $ 32.85万
  • 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    7217260
  • 财政年份:
    2003
  • 资助金额:
    $ 32.85万
  • 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    7618885
  • 财政年份:
    2003
  • 资助金额:
    $ 32.85万
  • 项目类别:
Stress-Induced Alterations in Amygdala-LC Interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    7645265
  • 财政年份:
    2003
  • 资助金额:
    $ 32.85万
  • 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    6721245
  • 财政年份:
    2003
  • 资助金额:
    $ 32.85万
  • 项目类别:

相似海外基金

Identifying the causal role of the amygdala in human approach-avoidance conflict behavior test
确定杏仁核在人类接近-回避冲突行为测试中的因果作用
  • 批准号:
    10516014
  • 财政年份:
    2021
  • 资助金额:
    $ 32.85万
  • 项目类别:
Identifying the causal role of the amygdala in human approach-avoidance conflict behavior test
确定杏仁核在人类接近-回避冲突行为测试中的因果作用
  • 批准号:
    10549552
  • 财政年份:
    2021
  • 资助金额:
    $ 32.85万
  • 项目类别:
Context Effects of Mobile Consumer Behavior: Test of Affect and Regulatory Focus Theory in Shopping and Investment Decisions
移动消费者行为的情境效应:购物和投资决策中的影响和监管焦点理论检验
  • 批准号:
    414986791
  • 财政年份:
  • 资助金额:
    $ 32.85万
  • 项目类别:
    Research Grants
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了