Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
基本信息
- 批准号:7618885
- 负责人:
- 金额:$ 7.88万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2003
- 资助国家:美国
- 起止时间:2003-04-01 至 2009-03-31
- 项目状态:已结题
- 来源:
- 关键词:AcousticsAcuteAddressAffectAmygdaloid structureAnimalsArtsBehaviorBehavioralBehavioral SymptomsChronicChronic stressComplexCorticotropin-Releasing HormoneCyclic AMPDataDiseaseDrug abuseElectric StimulationEtiologyExhibitsExposure toFire - disastersFunctional disorderHippocampus (Brain)In VitroInfusion proceduresInterruptionInvestigationLeadLesionMeasuresMediatingMediationMental disordersMethodsN-MethylaspartateNatureNeuronsNorepinephrineNumbersPathway interactionsPharmaceutical PreparationsPhysiologicalPhysiologyPlayPotassiumProsencephalonRattusRegulationRelapseRoleSecond Messenger SystemsShockStimulusStressStructure of terminal stria nuclei of preoptic regionSystemTailTestingTimebiological adaptation to stressdayin vivoindexinginsightlocus ceruleus structureneurochemistrynoradrenergicnorepinephrine systemnovelpreventresponsesciatic nervesecond messengerstressor
项目摘要
Stress is known to be a factor in the etiology or exacerbation of psychiatric disorders, and plays an
important role in reinstatement of drug-taking behavior. This proposal will use primarily electrophysiologic-
al recordings in anesthetized rats to examine the effects of acute and chronic stress on the regulation of
the locus coeruleus (LC) by the amygdalar complex. Norepinephrine and corticotropin releasing hormone
have been identified as central factors in the response to stress. In particular, the noradrenergic neurons
of the LC are known to have a major role in central mediation of stress responses. These neurons are
driven by a number of afferent influences. One set of afferents that appears to have a primary role in
stress as it relates to psychiatric disorders and relapse to drug abuse are the projections that involve the
amygdala. We propose to examine amygdalar regulation of LC neuron activity, and how this system is
modified by acute and chronic stress. Our central hypothesis is that chronic stress causes a sensitization
of LC neuron responsivity via its effects on amygdalofugal pathways. This will be done along four specific
aims: 1) to examine the physiology of projection systems connecting the basolateral amygdala complex
with the LC, 2) to examine the response of this system to acute stressors (footshock), and how these
responses are modified following chronic cold exposure, 3) to evaluate the nature of the change in LC
neuron responsivity following chronic stress, and 4) to determine whether the alteration in LC responsivity
following chronic stress can be altered by selective interruption of these amygdalar efferents. We will use
primarily in vivo single unit and intracellular recording methods to examine systems-level interactions,
with in vitro recordings used to measure persistent changes in LC neuronal activity and to address
specific pathway-related questions as they arise. We will independently verify the behavioral effects of
chronic cold exposure by measuring acoustic startle, a response that is sensitive to manipulations of the
central amygdala and forebrain NE systems. We hope that a better understanding of amygdalar-
coerulear systems will lead to insights into how stress-induced pathophysiology in these pathways can, in
)art, mediate some of the behavioral symptoms of psychiatric disease and drug-abuse disorders.
众所周知,压力是精神疾病的病因或恶化的一个因素,并在
在恢复吸毒行为方面发挥重要作用。这项提议将主要使用电生理学-
急性应激和慢性应激对麻醉大鼠脑电活动调节的影响
杏仁复合体周围的蓝斑(LC)。去甲肾上腺素和促肾上腺皮质激素释放激素
已经被认为是应对压力的核心因素。尤其是去甲肾上腺素能神经元
已知LC在应激反应的中枢调节中起着重要作用。这些神经元是
受一些传入影响的驱使。一组传入神经似乎在
压力与精神障碍和药物滥用复发有关,这些预测涉及
杏仁核。我们建议研究杏仁核对LC神经元活性的调节,以及这个系统是如何
受到急性和慢性压力的影响。我们的中心假设是慢性压力会引起敏感化
通过其对杏仁核通路的影响来研究LC神经元的反应性。这将沿着四个具体的步骤来完成
目的:1)检查连接杏仁基底外侧复合体的投射系统的生理学
使用LC,2)检查该系统对急性应激源(足底电击)的反应,以及这些反应如何
慢性冷暴露后的反应被修改,3)评估LC变化的性质
慢性应激后的神经元反应性,以及4)确定LC反应性的改变
慢性应激可通过选择性阻断杏仁核的传出改变。我们将使用
主要是体内单一单位和细胞内记录方法,以检查系统级别的相互作用,
使用体外记录来测量LC神经元活动的持续变化并解决
出现特定的与路径相关的问题。我们将独立验证
通过测量声惊厥来测量慢性冷暴露,这是一种对操纵
中央杏仁核和前脑NE系统。我们希望对杏仁核有更好的了解-
蓝斑系统将引导人们深入了解应激诱导的这些通路中的病理生理学如何在
)ART,调解精神疾病和药物滥用障碍的一些行为症状。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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ANTHONY A GRACE其他文献
ANTHONY A GRACE的其他文献
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{{ truncateString('ANTHONY A GRACE', 18)}}的其他基金
Circuit-based Study of Depression/Anhedonia in Rats
大鼠抑郁/快感缺失的回路研究
- 批准号:
8694160 - 财政年份:2014
- 资助金额:
$ 7.88万 - 项目类别:
Circuit-based Study of Depression/Anhedonia in Rats
大鼠抑郁/快感缺失的回路研究
- 批准号:
9043194 - 财政年份:2014
- 资助金额:
$ 7.88万 - 项目类别:
Circumventing physiological consequences of drug abuse
规避药物滥用的生理后果
- 批准号:
8661742 - 财政年份:2013
- 资助金额:
$ 7.88万 - 项目类别:
Circumventing physiological consequences of drug abuse
规避药物滥用的生理后果
- 批准号:
8598969 - 财政年份:2013
- 资助金额:
$ 7.88万 - 项目类别:
In vivo neurocircuitry of DBS response in rodents
啮齿类动物 DBS 反应的体内神经回路
- 批准号:
8076854 - 财政年份:2010
- 资助金额:
$ 7.88万 - 项目类别:
INTEGRETIVE INFLUENCES OF THALAMIC/CORTICAL INPUTS--PREFRONTAL CORTICAL FUNCTION
丘脑/皮质输入的整体影响——前额皮质功能
- 批准号:
7553450 - 财政年份:2007
- 资助金额:
$ 7.88万 - 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
- 批准号:
6919221 - 财政年份:2003
- 资助金额:
$ 7.88万 - 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
- 批准号:
7217260 - 财政年份:2003
- 资助金额:
$ 7.88万 - 项目类别:
Stress-Induced Alterations in Amygdala-LC Interactions
压力引起的杏仁核-LC 相互作用的改变
- 批准号:
7645265 - 财政年份:2003
- 资助金额:
$ 7.88万 - 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
- 批准号:
6721245 - 财政年份:2003
- 资助金额:
$ 7.88万 - 项目类别:
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