Stress-induced alterations in amygdala-LC interactions

压力引起的杏仁核-LC 相互作用的改变

基本信息

  • 批准号:
    7618885
  • 负责人:
  • 金额:
    $ 7.88万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2003
  • 资助国家:
    美国
  • 起止时间:
    2003-04-01 至 2009-03-31
  • 项目状态:
    已结题

项目摘要

Stress is known to be a factor in the etiology or exacerbation of psychiatric disorders, and plays an important role in reinstatement of drug-taking behavior. This proposal will use primarily electrophysiologic- al recordings in anesthetized rats to examine the effects of acute and chronic stress on the regulation of the locus coeruleus (LC) by the amygdalar complex. Norepinephrine and corticotropin releasing hormone have been identified as central factors in the response to stress. In particular, the noradrenergic neurons of the LC are known to have a major role in central mediation of stress responses. These neurons are driven by a number of afferent influences. One set of afferents that appears to have a primary role in stress as it relates to psychiatric disorders and relapse to drug abuse are the projections that involve the amygdala. We propose to examine amygdalar regulation of LC neuron activity, and how this system is modified by acute and chronic stress. Our central hypothesis is that chronic stress causes a sensitization of LC neuron responsivity via its effects on amygdalofugal pathways. This will be done along four specific aims: 1) to examine the physiology of projection systems connecting the basolateral amygdala complex with the LC, 2) to examine the response of this system to acute stressors (footshock), and how these responses are modified following chronic cold exposure, 3) to evaluate the nature of the change in LC neuron responsivity following chronic stress, and 4) to determine whether the alteration in LC responsivity following chronic stress can be altered by selective interruption of these amygdalar efferents. We will use primarily in vivo single unit and intracellular recording methods to examine systems-level interactions, with in vitro recordings used to measure persistent changes in LC neuronal activity and to address specific pathway-related questions as they arise. We will independently verify the behavioral effects of chronic cold exposure by measuring acoustic startle, a response that is sensitive to manipulations of the central amygdala and forebrain NE systems. We hope that a better understanding of amygdalar- coerulear systems will lead to insights into how stress-induced pathophysiology in these pathways can, in )art, mediate some of the behavioral symptoms of psychiatric disease and drug-abuse disorders.
众所周知,压力是精神疾病病因或恶化的一个因素,并在其中起着重要作用

项目成果

期刊论文数量(0)
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专利数量(0)

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ANTHONY A GRACE其他文献

ANTHONY A GRACE的其他文献

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{{ truncateString('ANTHONY A GRACE', 18)}}的其他基金

Circuit-based Study of Depression/Anhedonia in Rats
大鼠抑郁/快感缺失的回路研究
  • 批准号:
    8694160
  • 财政年份:
    2014
  • 资助金额:
    $ 7.88万
  • 项目类别:
Circuit-based Study of Depression/Anhedonia in Rats
大鼠抑郁/快感缺失的回路研究
  • 批准号:
    9043194
  • 财政年份:
    2014
  • 资助金额:
    $ 7.88万
  • 项目类别:
Circumventing physiological consequences of drug abuse
规避药物滥用的生理后果
  • 批准号:
    8661742
  • 财政年份:
    2013
  • 资助金额:
    $ 7.88万
  • 项目类别:
Circumventing physiological consequences of drug abuse
规避药物滥用的生理后果
  • 批准号:
    8598969
  • 财政年份:
    2013
  • 资助金额:
    $ 7.88万
  • 项目类别:
In vivo neurocircuitry of DBS response in rodents
啮齿类动物 DBS 反应的体内神经回路
  • 批准号:
    8076854
  • 财政年份:
    2010
  • 资助金额:
    $ 7.88万
  • 项目类别:
INTEGRETIVE INFLUENCES OF THALAMIC/CORTICAL INPUTS--PREFRONTAL CORTICAL FUNCTION
丘脑/皮质输入的整体影响——前额皮质功能
  • 批准号:
    7553450
  • 财政年份:
    2007
  • 资助金额:
    $ 7.88万
  • 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    6919221
  • 财政年份:
    2003
  • 资助金额:
    $ 7.88万
  • 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    7217260
  • 财政年份:
    2003
  • 资助金额:
    $ 7.88万
  • 项目类别:
Stress-Induced Alterations in Amygdala-LC Interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    7645265
  • 财政年份:
    2003
  • 资助金额:
    $ 7.88万
  • 项目类别:
Stress-induced alterations in amygdala-LC interactions
压力引起的杏仁核-LC 相互作用的改变
  • 批准号:
    6721245
  • 财政年份:
    2003
  • 资助金额:
    $ 7.88万
  • 项目类别:

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