HR-QOL in Colorectal Cancer Survivors with Stomas

描述（由申请人提供）： 这项多方法横断面研究的目的是确定长期结肠直肠癌生存者（诊断后> 5年）肠造口的健康相关生活质量（HR-QOL）问题，并将这些问题与基础疾病状态、造口时间、合并症以及其他人口统计学特征（如年龄、性别和种族）联系起来。此外，还将探讨适应造口的技能和方法以及持续存在的挑战，以收集有关可能有助于改善这些患者HR-QOL的潜在干预措施的见解。长期目标是产生有针对性的创新心理社会干预措施，旨在促进适应造口的挑战和影响长期结肠直肠癌生存者的HR-QOL的因素与造口。根据研究结果，将制定一项研究计划，以测试干预措施。研究方法将包括使用经过充分验证的工具收集HR-QOL数据，通过邮寄方式对两个大型多种族Kaiser Permanente地区接受治疗的长期（诊断后> 5年）结直肠癌幸存者（有或无造口）进行调查。在调查完成后，将举行焦点小组，男性和女性分开，调查应对技能和障碍的HR-QOL的最高和最低的四分位数。最后一步将是召集供应商调查员，根据研究结果为未来的干预措施和传播方法提出建议。

DESCRIPTION (provided by applicant): The purpose of this multi-method cross-sectional study is to identify health-related Quality of Life (HR-QOL) concerns specific to long-term colorectal cancer survivors (> 5 years from diagnosis) with intestinal stomas and relate those concerns to underlying disease state, time with stoma, comorbidities, as well as other demographic characteristics such as age, gender, and ethnicity. In addition, the skills and methods of adaptation to ostomies, as well as persisting challenges will be explored to gather insights about potential interventions that may be useful to improving HR-QOL for these patients. Long-term objectives are to generate targeted innovative psychosocial interventions designed to facilitate adaptation to stomal challenges and factors impinging on HR-QOL in long-term colorectal cancer survivors with stomas. Based on study results, a program of research will be developed to test interventions. Study methods will include collection of HR-QOL data using well-validated instruments in a mailed survey of long-term (> 5 years after diagnosis) colorectal cancer survivors with and without ostomies who are in care in two large, multiethnic Kaiser Permanente regions. Following completion of the survey, focus groups will be held, separate for men and women, to investigate the coping skills and barriers for those in the highest and lowest quartiles of HR-QOL. The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings.