HR-QOL in Colorectal Cancer Survivors with Stomas

描述(由申请人提供)： 这项多方法横断面研究的目的是确定患有肠造口的长期结直肠癌幸存者(确诊后5年)的健康相关生活质量(HR-QOL)问题，并将这些问题与潜在的疾病状态、造口时间、合并症以及其他人口学特征如年龄、性别和种族联系起来。此外，将探索适应造口的技能和方法，以及持续存在的挑战，以收集有关可能有助于改善这些患者的HR-QOL的潜在干预措施的见解。长期目标是产生有针对性的创新心理社会干预措施，旨在促进对造口挑战和影响结肠直肠癌长期存活者HR-QOL的因素的适应。根据研究结果，将制定一项研究计划来测试干预措施。研究方法将包括在一项邮寄调查中使用经过良好验证的工具收集HR-QOL数据，调查对象是在两个大型、多种族的Kaiser Permanente地区接受护理的长期(确诊5年后)有造口和没有造口的结直肠癌幸存者。调查完成后，将分别为男性和女性举行焦点小组，以调查HR-QOL中最高和最低四分位数的人的应对技能和障碍。最后一步将是召集提供者调查人员，根据研究结果对未来的干预和传播方法提出建议。

DESCRIPTION (provided by applicant): The purpose of this multi-method cross-sectional study is to identify health-related Quality of Life (HR-QOL) concerns specific to long-term colorectal cancer survivors (> 5 years from diagnosis) with intestinal stomas and relate those concerns to underlying disease state, time with stoma, comorbidities, as well as other demographic characteristics such as age, gender, and ethnicity. In addition, the skills and methods of adaptation to ostomies, as well as persisting challenges will be explored to gather insights about potential interventions that may be useful to improving HR-QOL for these patients. Long-term objectives are to generate targeted innovative psychosocial interventions designed to facilitate adaptation to stomal challenges and factors impinging on HR-QOL in long-term colorectal cancer survivors with stomas. Based on study results, a program of research will be developed to test interventions. Study methods will include collection of HR-QOL data using well-validated instruments in a mailed survey of long-term (> 5 years after diagnosis) colorectal cancer survivors with and without ostomies who are in care in two large, multiethnic Kaiser Permanente regions. Following completion of the survey, focus groups will be held, separate for men and women, to investigate the coping skills and barriers for those in the highest and lowest quartiles of HR-QOL. The final step will be to convene provider investigators to make recommendations for future interventions and dissemination methods based upon study findings.