Skeletal Development and Remodeling in Health, Disease and Aging

健康、疾病和衰老中的骨骼发育和重塑

• 批准号: 7001960
• 负责人: Mone Zaidi
• 金额: $ 1.3万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-16 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7001960
• 关键词: aging; bone development; bone regeneration; cell biology; endocrinology; meeting /conference /symposium; molecular biology; osteocytes; osteoporosis; physiologic bone resorption; travel

DESCRIPTION (provided by applicant): The New York Academy of Sciences (NYAS) is planning a conference titled, "Skeletal Development and Remodeling in Health, Disease and Aging" to be held from May 18 to March 21, 2005 in New York City. The conference is being organized by Mone Zaidi, MD, PhD, FRCP, Professor of Medicine and Director, Mount Sinai Bone Program, Mount Sinai School of Medicine. It is an ideal time for a conference on this subject, as the past decade has seen an enormous expansion in our understanding of how the skeleton is remodeled and repaired. Using state-of-the-art molecular technologies including Tran genesis, gene knockout, and gene array, scientists are gaining a better understanding of both the precise pathways through which osteoblasts lay down new bone and how osteoclasts remove old bone. These studies have helped clarify basic biological properties of the skeleton, how it responds to hormonal, cytokine and mechanical stimulation, as well as clarified path physiology. The eventual goal of such discoveries is to lay down a firm scientific foundation for the identification of novel cellular and molecular targets for future drug development. The conference will be organized along four themes: Skeletal Development and Repair, Molecular Endocrinology of Bone, Bone Cell Biology and Conservation of Skeletal Integrity, while enabling participants to engage in a highly focused discussion within each category. The final day will specifically focus on current and emerging therapies for osteoporosis. The conference will draw wide spread participation among high powered contributors in bone and cartilage biology research, as well as junior faculty member and senior postdoctoral research fellows working in the field. We also expect the meeting to be attended also by biologists, chemists, and medical doctors whose research and/or patients stand to benefit from the information exchanged at the conference. A local forum, which will provide the non-scientific public an informal opportunity to learn about the latest research and therapies emerging in the field, is also planned.

描述（由申请人提供）： 纽约科学院 (NYAS) 计划于 2005 年 5 月 18 日至 3 月 21 日在纽约市举行一次题为“健康、疾病和衰老中的骨骼发育和重塑”的会议。该会议由西奈山医学院医学教授兼西奈山骨骼项目主任 Mone Zaidi（医学博士、博士、皇家内科医师学会会员）组织。 现在是召开有关该主题的会议的理想时机，因为在过去的十年中，我们对骨骼如何重塑和修复的理解有了巨大的扩展。利用包括转基因、基因敲除和基因阵列在内的最先进的分子技术，科学家们正在更好地了解成骨细胞沉积新骨的精确途径以及破骨细胞如何去除旧骨。这些研究有助于阐明骨骼的基本生物学特性，它如何对激素、细胞因子和机械刺激做出反应，并阐明了路径生理学。这些发现的最终目标是为未来药物开发的新型细胞和分子靶标的鉴定奠定坚实的科学基础。 会议将围绕四个主题组织：骨骼发育与修复、骨分子内分泌学、骨细胞生物学和骨骼完整性保护，同时使与会者能够在每个类别内进行高度集中的讨论。最后一天将特别关注当前和新兴的骨质疏松症疗法。会议将吸引骨和软骨生物学研究领域的杰出贡献者以及该领域的初级教员和高级博士后研究员的广泛参与。我们还希望生物学家、化学家和医生也能参加会议，他们的研究和/或患者将从会议上交换的信息中受益。还计划举办一个当地论坛，为非科学公众提供了解该领域最新研究和疗法的非正式机会。