Skeletal Biology and Medicine Conference

描述(由申请者提供)：纽约科学院(NYAS)计划于2007年4月25日至28日在纽约科学院和纽约西奈山医学中心举行为期4天的大型会议，题为“骨骼生物学和医学”。会议由医学博士、FRCP医学和生理学教授、西奈山骨骼项目主任Mone Zaidi组织。对骨发育机制的新见解，包括细胞和力学因素、受体和信号通路，有助于我们理解骨和骨骼的正常和病理状态。骨细胞经历动态过程，受众多遗传因素和细胞介体的影响。最近的发现正在形成治疗方向，将重点放在多种干预模式上，包括抗吸收治疗和合成代谢药物。同样重要的是其他生理系统或疾病状态，如免疫系统、炎症、感染和癌症对骨骼和肌肉骨骼健康的作用。更好地了解骨骼生物学的基本原理、与骨骼疾病有关的病理生理学以及其中一些疾病的分子和遗传学基础将影响找到有效治疗方法的能力。这次会议将在一个论坛上结合基础、临床和转化性研究，旨在提供有关骨骼发育及其与骨骼疾病及其治疗的关系的最新信息。这次会议的具体目标是：1)研究骨骼发育的生理学；2)探索骨骼疾病的病理生理学；3)讨论改进的骨病治疗模式；4)通过印刷和电子手段传播会议记录，使更多的受众能够从分享的见解中受益。

DESCRIPTION (provided by applicant): The New York Academy of Sciences (NYAS) is planning a major 4-day conference entitled "Skeletal Biology and Medicine" to be held April 25-28, 2007 at the New York Academy of Sciences and the Mount Sinai Medical Center, New York, NY. The conference is being organized by Mone Zaidi, MD, PhD, FRCP, Professor of Medicine and Physiology, Director Mount Sinai Bone Program. New insights into the mechanisms of bone development including cellular and mechanical factors, receptors, and signaling pathways have contributed to our understanding of both normative and pathologic states of bone and the skeleton. Bone cells undergo dynamic processes whereby they are influenced by numerous genetic factors and cellular mediators. Recent findings are shaping therapeutic directions to focus on multiple modes of intervention involving anti-resorptive treatments and anabolic agents. Also significant is the role that other physiological systems or disease states such as the immune system, inflammation, infection and cancer have on bone and musculoskeletal health. A better understanding of the fundamentals of skeletal biology, the pathophysiology associated with skeletal disease and the molecular and genetic basis for some of these disorders will impact on the ability to find effective treatments. This conference will combine basic, clinical and translational research in a forum designed to provide the most current information on aspects of skeletal development and its relationship to bone disease and its treatment. Specific objectives of this conference are to: 1) examine the physiology of bone development; 2) explore the pathophysiology, of skeletal diseases; 3) discuss improved treatment paradigms for bone disease and 4) disseminate the proceedings by print and electronic means so that a wider audience can benefit from the insights shared.