3rd Skeletal Biology and Medicine Conference

描述（由申请人提供）：纽约骨骼生物学和医学（nyysbm）是2005年开始的一系列两年一次的会议中的第三次国际会议，最初由纽约科学院和西奈山医学院联合主办。本次会议的目标受众包括基础科学家、临床研究人员和临床医生，他们对内分泌学、生理学、细胞生物学、病理学、遗传学、分子生物学、风湿病学、放射学、骨科和肿瘤学等不同学科感兴趣，因为它们与骨骼发育、体内平衡和健康有关。以前的会议有多达200名与会者，其中多达80名在基础和临床骨病的各个领域的专家被邀请发言或主持会议。历年来的会议深受世界各地与会者的珍视。上届会议特别邀请了来自以色列海法的2004年诺贝尔化学奖得主Aaron cihanover博士进行全体会议和特邀演讲。它还包括约翰·波茨（哈佛医学院）的罗莎琳·耶洛讲座和杰拉德·卡森蒂（哥伦比亚大学）的吉迪恩·罗丹纪念讲座。这次会议现在被认为是骨骼代谢领域的首次会议，因此已经成为一个必要的会议。会议提供了对骨发育和重建机制的重要见解，包括细胞和机械触发，受体和信号通路。过去的两次会议对我们对骨和骨骼的规范和病理状态的理解做出了重大贡献。骨细胞经历动态过程，受遗传因素和细胞介质的影响。最近的研究结果正在塑造治疗方向，集中于多种干预模式，包括抗吸收和重要的合成代谢药物。同样重要的是其他生理系统或疾病状态，如免疫系统、炎症、糖尿病、感染和癌症对骨骼和肌肉骨骼健康的影响。更好地了解骨骼生物学的基本原理，与骨骼疾病相关的病理生理学以及这些疾病的分子和遗传基础将影响我们找到有效治疗方法的能力。2009年NYSMB将在一个论坛上结合基础、临床和转化研究，旨在提供有关骨骼发育及其与骨骼疾病及其治疗的关系方面的最新信息。

DESCRIPTION (provided by applicant): The New York Skeletal Biology and Medicine (NYSBM) is the third international conference in a series of biennial meetings that began in 2005, initially under the joint auspices of the New York Academy of Sciences and Mount Sinai School of Medicine. The target audience for this conference comprises of basic scientists, clinical investigators and clinicians with interests in diverse disciplines of endocrinology, physiology, cell biology, pathology, genetics, molecular biology, rheumatology, radiology, orthopedics and oncology as they relate to bone development, homeostasis and health. The previous conferences have had up to 200 participants, of which up to 80 experts in various areas of basic and clinical bone disease were invited to speak or chair sessions. The past years' meetings have been cherished by the participants and attendees from all parts of the world. The past meeting, in particular, featured amongst other plenary and invited lectures, Dr. Aaron Ciechanover, Nobel Laureate in Chemistry (2004) from Haifa, Israel. It also featured the Rosalyn Yalow Lecture given by John Potts (Harvard Medical School) and the Gideon Rodan Memorial Lecture given by Gerard Karsenty (Columbia). The conference now commands the reputation as being a premiere meeting in skeletal metabolism, and has therefore become an imperative. The conference provides vital insights into the mechanisms of bone development and restructuring, including cellular and mechanical triggers, receptors and signaling pathways. The past two meetings have contributed significantly to our understanding of both normative and pathologic states of bone and the skeleton. Bone cells undergo dynamic processes, where by they are influenced by genetic factors and cellular mediators. Recent findings are shaping therapeutic directions to focus on multiple modes of intervention involving anti-resorptive and importantly anabolic agents. Also significant is the role that other physiological systems or disease states such as the immune system, inflammation, diabetes, infection and cancer have on bone and musculoskeletal health. A better understanding of the fundamentals of skeletal biology, the pathophysiology associated with skeletal disease and the molecular and genetic basis of these disorders will impact on our ability to find effective treatments. The 2009 NYSMB will combine basic, clinical and translational research in a forum designed to provide the most current information on aspects of skeletal development and its relationship to bone disease and its treatment.