Genetic Recombination/Genomic Rearrangements Conference

描述（由申请人提供）：本申请为2003年和2005年FASEB基因重组和基因组重排夏季研究会议申请部分资金。2003年的会议将于7月26日至31日在科罗拉多州的斯诺马斯村举行，这将是一系列非常成功的两年一次的基因重组会议的第十次会议。在这些会议上，研究人员在一系列生物系统和不同的实验方法中研究基因重组的许多不同方面。演讲将介绍有关该领域及时问题的新的和未发表的工作，并鼓励所有参与者进行讨论。八场全体会议将涉及重组机制、原核和真核重组的性质、减数分裂过程、重组过程在修复DNA损伤中的作用、位点特异性重组和转位以及基因组重排等主题。40位演讲者，在这些特定领域中最优秀的实验家和思想家，已经同意展示他们最近和未发表的工作。几个及时的问题将被讨论，包括乳腺癌易感基因BRCA2在重组控制中的作用，重组在复制叉修复中的作用和细胞周期检查点对DNA损伤的反应及其对修复和重组的影响。利用哺乳动物和其他模型遗传系统，将讨论已知的重组和修复因子的特征，这些因子是人类综合症的基础，将倾向于癌症。大约160名其他与会者将从会议的申请者中选出。在选择参与者时保持严格的卓越标准的同时，将尽一切努力实现年龄、性别、种族和地域的平衡代表。所有人都将被鼓励参加讨论、研讨会和海报会议。将有一个关于一个有争议的话题的讲习班，Mus81复合体在重组中间加工中的作用，以及两次海报会议，每次持续两天，将提供一个额外的论坛，介绍当前的工作。2005年的会议安排与此类似，但将邀请不同的演讲者。通过在中等规模的会议环境中强调真正杰出的研究，FASEB会议为重组领域的新老研究人员之间的信息，技术和观点交流提供了独特的机会。

DESCRIPTION (provided by applicant): This application requests partial funding for the 2003 and 2005 FASEB summer research conference on Genetic Recombination and Genomic Rearrangements. The 2003 conference will be held July 26-31 at Snowmass village, Colorado and will be the tenth of a highly successful series of bi-annual conferences on genetic recombination. These conferences join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will encourage discussion from all participants. Eight plenary sessions will involve topics such as recombination mechanisms, properties of prokaryotic and eukaryotic recombination, meiotic processes, the role of recombinational processes in repair of DNA damage, site-specific recombination and transposition, and genomic rearrangements. Forty speakers, among the best experimentalists and thinkers in these particular areas, have agreed to present their most recent and unpublished work. Several timely issues will be discussed including the role of the breast cancer susceptibility gene BRCA2 in the control of recombination, the role of recombination in repair of the replication fork and the cell cycle checkpoint response to DNA damage and its influence on repair and recombination. Characterization of recombination and repair factors known to underlie human syndromes will propensity to cancer will be discussed, using mammalian and other model genetic systems. Approximately 160 other participants will be chosen from among the applicants to the conference. While maintaining rigorous standards of excellence in selecting participants, every attention will be paid to achieving a balanced representation of age, gender, race and geography. All will be encouraged to participate in discussion, workshops and poster sessions. There will be a workshop on a controversial topic, the role of the Mus81 complexes in recombination intermediate processing, and two poster sessions, each lasting two days, will provide an additional forum for presentation of current work. The 2005 will be organized similarly but will feature different speakers. By emphasizing truly exceptional research in a modestly sized conference setting, the FASEB conference provide unique opportunities for the exchange of information, technology and perspective among new and established investigators in the recombination field.