Genome and Epigenome Integrity In Cancer

癌症中的基因组和表观基因组完整性

• 批准号: 10667628
• 负责人: Lorraine S Symington
• 金额: $ 41.52万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10667628
• 关键词: Genome; Malignant Neoplasms; epigenome

This proposal seeks support for predoctoral students and postdoctoral fellows focused on genome and epigenome integrity in cancer. Two fundamental processes that drive cancer development are genetic mutations (genome instability) and epigenome reprogramming (epigenome instability). Historically, genome and epigenome integrity have been studied as separate disciplines. Scientifically, however, the genome and epigenome integrity are inherently connected by chromatin, an organized complex of DNA, protein and RNA. Therefore, there is a growing need for future scientists who can bridge these two disciplines to advance cancer research in a paradigm-shifting way. Recently, Columbia University has emerged as a leading institution for research and education in genome and epigenome integrity in cancer. Therefore, we propose to create the nation’s first Genome and Epigenome Integrity in Cancer (GEIC) Training Program to foster next generation scientists in these two interconnected disciplines of cancer research. To do so, we will leverage the expertise of our faculty, state-of-the-art resources at Columbia University and exceptional support from the Herbert Irving Comprehensive Cancer Center (HICCC). The GEIC Program will be administered by two co-PIs with complementary scientific expertise in genome and epigenome integrity in cancer. The co-PIs will be advised by an Executive Committee and an Advisory Board. Program evaluation will be solicited from the Executive Committee and Advisory Board members, as well as annual anonymous surveys of trainees and mentors. The HICCC will also provide substantial support to the GEIC program by funding an additional slot for five years. The GEIC predoctoral trainees will be selected from students enrolled in the Columbia University Graduate School of Arts & Sciences who have completed the first-year of graduate studies and entered a GEIC laboratory to pursue their Ph.D. dissertation research in the areas of genome and epigenome integrity in cancer. Postdoctoral fellows will be selected from two sources, internal and external. Internal trainees will be selected from applicants already embarking on postdoctoral studies in the laboratories of GEIC Program Faculty. In addition, to increase the pool of outstanding postdoctoral applicants, as well as the diversity of our trainees, the GEIC Program will aggressively recruit external postdoctoral applicants. Each trainee is required to develop an individual training plan approved by the Program directors and Executive Committee and to participate in GEIC program organized/specified training activities. Progress in these training activities will be evaluated by the Program Directors, along with the Executive Committee and Advisory Board, before renewal of second year support. Finally, the Diversity Enhancement Committee will work with Program Directors to actively recruit underrepresented minority (URM) to the GEIC Program, with the goal of 25% GEIC trainees being URMs. We expect that the GEIC Training Program will foster next generation of scientists with diverse backgrounds specialized in genome and epigenome integrity in cancer.

该提案寻求对博士前学生和博士后研究员的支持，重点是基因组和 癌症中的表观基因组完整性两个驱动癌症发展的基本过程是基因突变 （基因组不稳定性）和表观基因组重编程（表观基因组不稳定性）。从历史上看，基因组和 表观基因组完整性已经作为独立的学科进行了研究。然而，科学家们认为， 表观基因组完整性通过染色质（DNA、蛋白质和RNA的有组织复合物）固有地连接。 因此，越来越需要能够弥合这两个学科以推进癌症的未来科学家 以一种范式转换的方式进行研究。最近，哥伦比亚大学已经成为一个领先的机构， 癌症基因组和表观基因组完整性的研究和教育。因此，我们建议设立 美国首个癌症基因组和表观基因组完整性（GEIC）培训计划，以培养下一代 这两个相互关联的癌症研究领域的科学家。为此，我们将利用 我们的教师，哥伦比亚大学最先进的资源和赫伯特欧文的特殊支持 综合癌症中心（CIMCC）。GEIC计划将由两个共同PI管理， 癌症基因组和表观基因组完整性方面的互补科学专长。共同PI将由以下人员提供建议： 一个执行委员会和一个咨询委员会。将向行政部门征求方案评估意见 委员会和咨询委员会成员，以及每年对受训人员和导师进行匿名调查。的 联合国环境规划署还将为GEIC方案提供实质性支持，为五年的额外时间段提供资金。的 GEIC博士预科生将从哥伦比亚大学研究生院招收的学生中选拔 完成第一年研究生学习并进入GEIC实验室， 攻读博士学位在癌症基因组和表观基因组完整性领域的论文研究。博士后 研究员将从内部和外部两个来源挑选。内部培训生将从申请人中挑选 已经开始在GEIC项目学院的实验室进行博士后研究。此外，为了增加 优秀的博士后申请者，以及我们的学员的多样性，GEIC计划将 积极招募外部博士后申请者。每个受训者都需要制定一项个人培训计划 计划主任和执行委员会批准的计划，并参与GEIC计划 组织/具体的培训活动。这些培训活动的进展情况将由该方案进行评估 在续签第二年支持之前，董事以及执行委员会和咨询委员会沿着。 最后，多样性增强委员会将与项目主管合作，积极招募 GEIC计划的目标是让25%的GEIC受训人员成为代表性不足的少数民族（URM）。我们 我希望GEIC培训计划能够培养出具有不同背景的下一代科学家 专门研究癌症的基因组和表观基因组完整性。