Modulation of sensory processing

感觉处理的调节

• 批准号: 7052952
• 负责人: KRISTIN A MACZKO
• 金额: $ 3.64万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7052952
• 关键词: auditory stimulus; behavioral /social science research tag; brain electrical activity; cues; electrostimulus; mesencephalon; neural information processing; neural transmission; neuroregulation; neurotransmitter receptor; owls; predoctoral investigator; sound perception; visual perception; visual stimulus

DESCRIPTION (provided by applicant): A critical function of the nervous system is to process sensory stimuli differentially according to their salience and behavioral importance. Little is known, however, about the mechanisms by which sensory responses are modulated in the brain. The barn owl has a highly evolved auditory localization system that is an excellent model for studying sensory processing. Preliminary experiments indicate that a midbrain cholinergic nucleus modulates responses in this system. The research proposed here will use electrical microstimulation to activate this nucleus, and address the following questions: 1) how does activation of this nucleus modulate neural responses to auditory and visual localization cues? 2) which neurotransmitter receptors mediate this modulation? This research will contribute to our understanding of the mechanisms by which the nervous system can regulate its responses to sensory input, which may ultimately result in new treatments for attentional disorders.

描述（由申请人提供）：神经系统的一个关键功能是根据它们的显著性和行为重要性对感觉刺激进行不同的处理。然而，我们对大脑调节感觉反应的机制知之甚少。仓鸮有一个高度进化的听觉定位系统，这是研究感觉处理的一个很好的模型。初步实验表明，中脑胆碱能核调节该系统的反应。本文提出的研究将使用电微刺激来激活该核，并解决以下问题：1)该核的激活如何调节对听觉和视觉定位线索的神经反应？2)哪种神经递质受体介导这种调节？这项研究将有助于我们理解神经系统调节其对感觉输入的反应的机制，这可能最终导致注意力障碍的新治疗方法。