Modulation of sensory processing

感觉处理的调节

• 批准号: 7275913
• 负责人: KRISTIN A MACZKO
• 金额: $ 1.82万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7275913
• 关键词: Address; Auditory; Barn Owls; Behavioral; Brain; Cell Nucleus; Cholinergic Agents; Class; Columbidae; Cues; Data; Disease; Exhibits; Fellowship; Individual; Maps; Mediating; Midbrain structure; Names; Nervous System Physiology; Nervous system structure; Neurons; Neurotransmitter Receptor; Neurotransmitters; Pharmacology; Procedures; Process; Property; Research; Sensory; Sensory Process; Site; Sound Localization; Study models; System; Techniques; Time; Visual; auditory stimulus; cholinergic; receptor; relating to nervous system; research study; response; sensory stimulus; visual receptive field; visual stimulus

DESCRIPTION (provided by applicant): A critical function of the nervous system is to process sensory stimuli differentially according to their salience and behavioral importance. Little is known, however, about the mechanisms by which sensory responses are modulated in the brain. The barn owl has a highly evolved auditory localization system that is an excellent model for studying sensory processing. Preliminary experiments indicate that a midbrain cholinergic nucleus modulates responses in this system. The research proposed here will use electrical microstimulation to activate this nucleus, and address the following questions: 1) how does activation of this nucleus modulate neural responses to auditory and visual localization cues? 2) which neurotransmitter receptors mediate this modulation? This research will contribute to our understanding of the mechanisms by which the nervous system can regulate its responses to sensory input, which may ultimately result in new treatments for attentional disorders.

描述（由申请人提供）：神经系统的一个关键功能是根据感觉刺激的显着性和行为重要性来区别处理它们。然而，人们对大脑中感觉反应的调节机制知之甚少。仓鸮拥有高度进化的听觉定位系统，是研究感觉处理的绝佳模型。初步实验表明，中脑胆碱能核调节该系统的反应。这里提出的研究将使用电微刺激来激活该核，并解决以下问题：1）该核的激活如何调节对听觉和视觉定位线索的神经反应？ 2）哪些神经递质受体介导这种调节？这项研究将有助于我们了解神经系统调节其对感觉输入的反应的机制，这可能最终导致注意力障碍的新治疗方法。