Broadband near-infrared spectroscopy based biomarkers in traumatic brain injury

基于宽带近红外光谱的创伤性脑损伤生物标志物

• 批准号: 2575398
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2575398
• 关键词: Broadband; near; infrared; spectroscopy; based

Objectives1. To introduce and integrate novel optical monitoring methods into neuromonitoring of severe traumatic brain injury patients on intensive care2. To cross-validate the optical biomarkers with the existing neuromonitoring modalities3. To propose a new, dynamic, metric of severity of injury combining the metabolic and cerebrovascular dynamics information from the combined neuromonitoringIntroductionIn management of patients on intensive care immediately following a severe traumatic brain injury (TBI) it is the role of neuro-monitoring to provide timely warnings and indications of changes in the development of the pathological processes. The current push for personalised medicine must necessarily rely heavily on those technologies. However, currently available long-termneuromonitoring techniques include mainly invasive measurements of intracranial pressure (ICP) and local brain tissue partial pressure of oxygen (PbtO2).

目标1.将新型光学监测方法引入并整合到重症监护的重型创伤性脑损伤患者的神经监测中2。交叉验证光学生物标志物与现有神经监测模式3。提出一种新的，动态的，损伤严重程度的度量结合代谢和脑血管动力学信息，从组合neuromonitoringIntroductionIn重症监护病人的管理后立即严重创伤性脑损伤（TBI），它的作用是神经监测，以提供及时的警告和指示的病理过程的发展变化。目前对个性化医疗的推动必然严重依赖这些技术。然而，目前可用的长期神经监测技术主要包括颅内压（ICP）和局部脑组织氧分压（PbtO2）的侵入性测量。