Biomechanics of spinal manipulation using a cat model

使用猫模型进行脊柱操纵的生物力学

• 批准号: 6884214
• 负责人: ALLYSON IANUZZI
• 金额: $ 2.86万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-01 至 2008-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6884214
• 关键词: alternative medicine; backache; biological models; biomechanics; cats; computational biology; human data; mathematics; neurophysiology; predoctoral investigator; spine

DESCRIPTION (provided by applicant): Spinal manipulation (SM) is an effective treatment for low back pain, though the mechanisms by which it is effective remain elusive. It has been theorized that SM initiates a beneficial neurophysiological response by stimulating mechanically sensitive neurons in the facet joint capsule (FJC). The neurophysiological response during SM-like loads has been investigated in cat models, while the biomechanics of SM have been studied mostly in humans during in vivo or cadaveric studies. These data are not easily related because little is known about how the biomechanical response of the human lumbar spine during SM relates to that of the cat. The specific aim of the proposed study is to determine the mathematical relationship between the mechanical states of human and cat lumbar FJCs during SM. Cat cadaveric spines will be mechanically tested during simulated physiological motions and SM. A mathematical relationship will be established to relate cat lumbar FJC strain magnitudes to those obtained from prior studies in human cadaveric lumbar spines. Using this scaling relationship, the neurophysiological data obtained from cat models in future studies can be used to estimate how biomechanically similar motions would affect human FJC afferents.

描述（由申请人提供）：脊柱推拿（SM）是一种有效的治疗腰痛的方法，尽管其有效的机制仍然难以捉摸。理论上，SM通过刺激小关节囊（FJC）中的机械敏感神经元来启动有益的神经生理学反应。SM样负荷期间的神经生理反应已在猫模型中进行了研究，而SM的生物力学主要在人体体内或尸体研究中进行了研究。这些数据是不容易相关的，因为很少有人知道如何在SM过程中的人腰椎的生物力学响应与猫。拟议的研究的具体目的是确定之间的数学关系的机械状态的人和猫腰椎FJCs在SM。猫尸体脊柱将在模拟生理运动和SM过程中进行力学测试。将建立一个数学关系，将猫腰椎FJC应变幅度与先前在人尸体腰椎研究中获得的应变幅度相关联。使用这种比例关系，在未来的研究中，从猫模型获得的神经生理学数据可以用来估计生物力学相似的运动将如何影响人类FJC传入。