Biomechanics of spinal manipulation using a cat model

描述（由申请人提供）：脊柱推拿（SM）是治疗腰痛的有效方法，但其有效机制尚不明确。从理论上讲，SM通过刺激小关节囊（FJC）中的机械敏感神经元启动有益的神经生理反应。SM类负荷的神经生理反应已经在猫模型中进行了研究，而SM的生物力学研究主要是在体内或尸体研究中进行的。这些数据不容易联系起来，因为我们对SM期间人类腰椎的生物力学反应与猫的生物力学反应之间的关系知之甚少。该研究的具体目的是确定SM过程中人类和猫腰椎FJCs力学状态之间的数学关系。猫尸体的脊柱将在模拟生理运动和SM中进行机械测试。将建立一个数学关系，将猫腰椎FJC应变大小与先前在人尸体腰椎研究中获得的应变大小联系起来。利用这种比例关系，未来研究中从猫模型中获得的神经生理学数据可以用来估计生物力学上相似的运动如何影响人类FJC传入事件。

DESCRIPTION (provided by applicant): Spinal manipulation (SM) is an effective treatment for low back pain, though the mechanisms by which it is effective remain elusive. It has been theorized that SM initiates a beneficial neurophysiological response by stimulating mechanically sensitive neurons in the facet joint capsule (FJC). The neurophysiological response during SM-like loads has been investigated in cat models, while the biomechanics of SM have been studied mostly in humans during in vivo or cadaveric studies. These data are not easily related because little is known about how the biomechanical response of the human lumbar spine during SM relates to that of the cat. The specific aim of the proposed study is to determine the mathematical relationship between the mechanical states of human and cat lumbar FJCs during SM. Cat cadaveric spines will be mechanically tested during simulated physiological motions and SM. A mathematical relationship will be established to relate cat lumbar FJC strain magnitudes to those obtained from prior studies in human cadaveric lumbar spines. Using this scaling relationship, the neurophysiological data obtained from cat models in future studies can be used to estimate how biomechanically similar motions would affect human FJC afferents.