Effects of lung water on mechanics and blood flow

描述（由申请人提供）：我们建议使用已建立的技术和新型功能磁共振技术对人体进行无创测量，并将这些实验方法与建模研究相结合，以阐明肺间质水肿早期阶段肺力学和肺血流异质性的变化。我们将利用30度的头部向下倾斜（HOT）来引起肺部液体含量的增加，从而引起肺间质水肿的早期阶段。这种肺液平衡快速和急性变化的模型将提供一种诱导肺力学变化和肺外周肺血流分布的方法。我们假设人体在30度高温下发生的肺液体平衡的改变会增加肺水、外周肺组织顺应性的异质性、气道阻力和肺血流的异质性。本研究具有相关性，提供(1)对早期肺间质水肿如何影响肺功能的6as/c理解，以及(2)可用于亚临床水肿诊断和治疗相关研究的模型。

DESCRIPTION (provided by applicant): We propose to perform noninvasive measurements in humans, using established techniques and novel functional magnetic resonance techniques, and combine these experimental approaches with modeling studies to elucidate changes in the heterogeneity of lung mechanics and pulmonary blood flow that occur during the early stages of pulmonary interstitial edema. We will utilize a 30-degree head-down tilt (HOT) to provoke an increase in fluid content of the lung, and consequently the early stages of pulmonary interstitial edema. This model of rapid and acute change in lung fluid balance will provide a means of inducing changes in lung mechanics and the distribution of pulmonary blood flow in the periphery of the lung. We hypothesize that the alteration in the fluid balance of the lung that occurs during 30-degree HOT in humans will increase lung water, heterogeneity of lung tissue compliance in the periphery, airway resistance, and heterogeneity of pulmonary blood flow. This study has relevance for providing (1) a 6as/c understanding of how the early stages of pulmonary interstitial edema affects lung function, and (2) a model that can be used for studies relating to the diagnosis and treatment of subclinical edema.