Effects of lung water on mechanics and blood flow

描述(申请人提供)：我们建议使用已有的技术和新的功能磁共振技术在人类身上进行非侵入性测量，并将这些实验方法与模拟研究相结合，以阐明肺间质水肿早期发生的肺力学和肺血流异质性的变化。我们将利用30度头朝下倾斜(热)来刺激肺内液体含量的增加，从而导致肺间质水肿的早期阶段。这种快速而急性的肺液平衡改变模型将提供一种诱导肺力学改变和肺血流在肺周围的分布的方法。我们假设，在30度高温期间，肺部液体平衡的改变会增加肺水，增加肺组织周围顺应性的异质性，增加呼吸道阻力，增加肺血流的不均一性。本研究的意义在于：(1)了解早期肺间质水肿对肺功能的影响；(2)为亚临床肺水肿的诊断和治疗提供一个模型。

DESCRIPTION (provided by applicant): We propose to perform noninvasive measurements in humans, using established techniques and novel functional magnetic resonance techniques, and combine these experimental approaches with modeling studies to elucidate changes in the heterogeneity of lung mechanics and pulmonary blood flow that occur during the early stages of pulmonary interstitial edema. We will utilize a 30-degree head-down tilt (HOT) to provoke an increase in fluid content of the lung, and consequently the early stages of pulmonary interstitial edema. This model of rapid and acute change in lung fluid balance will provide a means of inducing changes in lung mechanics and the distribution of pulmonary blood flow in the periphery of the lung. We hypothesize that the alteration in the fluid balance of the lung that occurs during 30-degree HOT in humans will increase lung water, heterogeneity of lung tissue compliance in the periphery, airway resistance, and heterogeneity of pulmonary blood flow. This study has relevance for providing (1) a 6as/c understanding of how the early stages of pulmonary interstitial edema affects lung function, and (2) a model that can be used for studies relating to the diagnosis and treatment of subclinical edema.