Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement
体力活动和减肥可改善全膝关节置换术后的功能和疼痛
基本信息
- 批准号:10711058
- 负责人:
- 金额:$ 27.95万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-01-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:AcuteAdultAerobicAlzheimer&aposs DiseaseBehaviorBehavioralBody Weight decreasedCardiovascular DiseasesCessation of lifeChronic DiseaseCognitionControl GroupsCrossover DesignDementiaDevelopmentDietDietary intakeEconomic BurdenExcess MortalityHealth Care CostsIndividualLife StyleMeasuresOperative Surgical ProceduresOutcomePainParentsParticipantPhysical FunctionPhysical activityRandomizedRestSelf ManagementSocietiesTestingWalkingWeightaging populationcognitive testingfunctional improvementhigh risk populationknee replacement arthroplastymortalitypreventprocessing speedprogramsprotective effectself-management programweight loss program
项目摘要
Project Summary/Abstract
The Parent R01 is examining the effects of a behavioral weight loss program as compared to a chronic
disease self-management (CDSM) program on weight, physical function, pain, and physical activity among
adults after total knee replacement (TKR). The proposed supplemental project aims to add an Alzheimer’s
disease and its related dementias (AD/ADRD) focus to our project by examining whether a behavioral weight
loss program and physical activity may have a protective effect against AD/ADRD among adults with TKR by
sustaining cognition. An increasing number of individuals are undergoing TKR, and although the surgery helps
to initially reduce mortality, the majority of deaths in the decades after surgery are from AD/ADRD and
cardiovascular disease. Healthcare costs from AD/ADRD are among the highest in the US, placing substantial
economic burden on society. Although the reasons for the excess mortality from AD/ADRD among adults with
TKR are unknown, strategies are needed to help reduce this population’s high risk for the development of
AD/ADRD as well as the corresponding economic burden that this surgery and conditions place on society.
The first Aim of the supplement is to examine the preliminary effects of a multicomponent (diet and physical
activity) weight loss program as compared to a CDSM control group on cognition at 6 months. The second Aim
will examine how changes in diet, aerobic physical activity, and weight are associated with cognition at 6
months. The final Aim is to examine the acute effects of a brief bout of walking on cognition. To examine aims
1 and 2, participants (n=60) will be randomized to one of two 12-month programs: (1) PACE weight loss
program or (2) CDSM. Assessments at baseline and 6 months will include measures of cognition, weight,
objectively-measured physical activity, and dietary intake. To examine aim 3, a cross-over design will be used
at the baseline assessment, in which participants (n=60) will be randomized to either Immediate or Delayed
walking conditions. Participants randomized to Immediate will complete the Six-min walking test first, whereas
participants randomized to delayed will complete the walking test after a 6-min rest period. A brief cognitive
test assessing processing speed will be completed 3 times at the baseline assessment to examine the effect of
an acute walking bout on cognition.
The expected outcome from this supplemental project is to determine the preliminary effects of
changes in weight, aerobic physical activity, and dietary intake on cognition in adults after TKR. If a behavioral
weight loss program and/or briefs bouts of activity can sustain cognition among an aging population, the
promotion of changes in these lifestyle behaviors could help to prevent or delay the onset of AD/ADRD.
项目总结/文摘
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A pooled analysis of the association between sarcopenia and osteoporosis.
- DOI:10.1097/md.0000000000031692
- 发表时间:2022-11-18
- 期刊:
- 影响因子:1.6
- 作者:Yu, Xiaochao;Sun, Shuo;Zhang, Shaoxiong;Hao, Qinggang;Zhu, Boheng;Teng, Yirong;Long, Qing;Li, Shujun;Lv, Yan;Yue, Qiaoning;Lu, Sheng;Teng, Zhaowei
- 通讯作者:Teng, Zhaowei
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Christine Ann Pellegrini其他文献
Christine Ann Pellegrini的其他文献
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{{ truncateString('Christine Ann Pellegrini', 18)}}的其他基金
Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement
体力活动和减肥可改善全膝关节置换术后的功能和疼痛
- 批准号:
10659134 - 财政年份:2021
- 资助金额:
$ 27.95万 - 项目类别:
Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement
体力活动和减肥可改善全膝关节置换术后的功能和疼痛
- 批准号:
10447172 - 财政年份:2021
- 资助金额:
$ 27.95万 - 项目类别:
Physical Activity and Weight Loss to Improve Function and Pain after Total Knee Replacement
体力活动和减肥可改善全膝关节置换术后的功能和疼痛
- 批准号:
10298376 - 财政年份:2021
- 资助金额:
$ 27.95万 - 项目类别:
Reducing Sedentary Time Using an Innovative mHealth Intervention Among Total Knee Replacement Patients
使用创新的移动医疗干预措施减少全膝关节置换患者的久坐时间
- 批准号:
10339457 - 财政年份:2020
- 资助金额:
$ 27.95万 - 项目类别:
Reducing Sedentary Time Using an Innovative mHealth Intervention Among Total Knee Replacement Patients
使用创新的移动医疗干预措施减少全膝关节置换患者的久坐时间
- 批准号:
10132987 - 财政年份:2020
- 资助金额:
$ 27.95万 - 项目类别:
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