A Tumor Tracking System for Image Guided Radiotherapy

用于图像引导放射治疗的肿瘤跟踪系统

• 批准号: 6985219
• 负责人: Steve Bin Jiang
• 金额: $ 26.07万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6985219
• 关键词: abdomen neoplasm; bioimaging /biomedical imaging; computer program /software; computer system design /evaluation; image guided surgery /therapy; mathematical model; neoplasm /cancer radiation therapy; phantom model; thorax neoplasm

DESCRIPTION (provided by applicant): Respiration induced organ motion during radiotherapy treatment delivery limits the capability for dose escalation and/or normal tissue sparing. The goal of this application is to improve the clinical outcome of radiotherapy for thoracic and abdominal tumors where respiratory motion is often an issue, by improving the precision of tumor localization during the treatment. This goal can be reached through the development of a well-engineered real-time tumor tracking system based an on-board x-ray imaging system that is currently being built by Massachusetts General Hospital (MGH) and Varian Medical Systems, Inc. (VMS). In the proposed project, through an expanded collaboration between MGH and VMS, we plan to develop a software framework and key function algorithms for the tracking system. The software framework will be developed by VMS by incorporating MGH's clinical perspectives, based on the framework of RPM Respiratory Gating System, a commercial product from VMS. Algorithms for the key functional blocks will be developed and tested mainly by MGH with technical assistance from VMS, using the software framework and the hardware platform as a test bed. he software framework and modules will be validated on the hardware platform using a computer-controlled dynamic phantom. The software system, combined with the hardware platform, will facilitate real-time tumor tracking with high precision and robustness. The system will be used for clinical trials to treat mobile tumors at MGH and can potentially be commercialized by VMS. The proposed project will greatly strengthen the relationship between MGH and VMS, leading to enhanced collaborative research activities as well as future research projects in the area of image guided radiotherapy.

描述（由申请人提供）：放射疗法治疗期间的呼吸诱导器官运动限制了剂量升级和/或正常组织保留的能力。该应用的目的是通过提高治疗过程中肿瘤定位的精度来改善呼吸运动通常是问题的胸腔和腹部肿瘤的临床结果。可以通过开发精心设计的实时肿瘤跟踪系统来实现此目标，该系统基于板载X射线成像系统，该系统目前由马萨诸塞州综合医院（MGH）和Varian Medical Systems，Inc。（VMS）建造。 在拟议的项目中，通过MGH和VM之间的扩展协作，我们计划为跟踪系统开发软件框架和关键功能算法。该软件框架将由VMS开发，通过将MGH的临床观点纳入RPM呼吸门控系统的框架，这是VMS的商业产品。将使用软件框架和硬件平台作为测试床开发和测试关键功能块的算法。 HE软件框架和模块将在硬件平台上使用计算机控制的动态幻影进行验证。 该软件系统与硬件平台结合使用，可以促进具有高精度和鲁棒性的实时肿瘤跟踪。该系统将用于临床试验，以治疗MGH的移动肿瘤，并有可能通过VM商业化。拟议的项目将极大地加强MGH与VM之间的关系，从而增强了合作研究活动以及图像指导放射疗法领域的未来研究项目。