A Tumor Tracking System for Image Guided Radiotherapy

用于图像引导放射治疗的肿瘤跟踪系统

• 批准号: 7555283
• 负责人: Steve Bin Jiang
• 金额: $ 12.61万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7555283
• 关键词: abdomen neoplasm; bioimaging /biomedical imaging; computer program /software; computer system design /evaluation; image guided surgery /therapy; mathematical model; neoplasm /cancer radiation therapy; phantom model; thorax neoplasm

DESCRIPTION (provided by applicant): Respiration induced organ motion during radiotherapy treatment delivery limits the capability for dose escalation and/or normal tissue sparing. The goal of this application is to improve the clinical outcome of radiotherapy for thoracic and abdominal tumors where respiratory motion is often an issue, by improving the precision of tumor localization during the treatment. This goal can be reached through the development of a well-engineered real-time tumor tracking system based an on-board x-ray imaging system that is currently being built by Massachusetts General Hospital (MGH) and Varian Medical Systems, Inc. (VMS). In the proposed project, through an expanded collaboration between MGH and VMS, we plan to develop a software framework and key function algorithms for the tracking system. The software framework will be developed by VMS by incorporating MGH's clinical perspectives, based on the framework of RPM Respiratory Gating System, a commercial product from VMS. Algorithms for the key functional blocks will be developed and tested mainly by MGH with technical assistance from VMS, using the software framework and the hardware platform as a test bed. he software framework and modules will be validated on the hardware platform using a computer-controlled dynamic phantom. The software system, combined with the hardware platform, will facilitate real-time tumor tracking with high precision and robustness. The system will be used for clinical trials to treat mobile tumors at MGH and can potentially be commercialized by VMS. The proposed project will greatly strengthen the relationship between MGH and VMS, leading to enhanced collaborative research activities as well as future research projects in the area of image guided radiotherapy.

描述（由申请人提供）：放射治疗递送过程中呼吸引起的器官运动限制了剂量递增和/或正常组织保留的能力。本应用程序的目的是通过提高治疗过程中肿瘤定位的精度，改善胸部和腹部肿瘤放射治疗的临床效果，因为呼吸运动经常是一个问题。这一目标可以通过开发基于机载x射线成像系统的精心设计的实时肿瘤跟踪系统来实现，该系统目前由马萨诸塞州总医院（MGH）和Varian医疗系统公司（VMS）共同开发。