Determination of Research Needs and Specifications of The Research Beam Line and Related Infrastructure

项目总监/首席调查员(最后、第一、中间)：蔡克 项目摘要 美国目前不向癌症患者提供比质子更重的离子辐射。那里 目前在亚洲有五个设施，在欧洲有两个机构治疗碳离子核患者，其中许多人 致力于临床试验，探索重离子疗法的每一项优势。德克萨斯大学西南分校创造了三个 建设包括质子在内的三模式德克萨斯先进放射治疗中心的分阶段提案 治疗(第一阶段)、光子治疗(第二阶段)和重离子治疗(第三阶段)设施。第一阶段已经开始了 在建设中，第二阶段也得到了资金，并处于建筑设计阶段。第三阶段正在规划中。 这个试点项目的目标是确定与使用带电的药物相关的潜在研究问题 放射治疗中的粒子和确定设计参数和技术指标的研究束线 以及相关的基础设施来解决这些问题。我们计划通过严格的、科学的、 有三个具体目标的全面和同行评议的方法：1)委员会的两项任务 负责对与使用 带电粒子治疗和设计束线和束流所需部件的规格 基础设施；2)确定国家颗粒研究中心的潜在研究范围；3)开发 与研究光束线、设施和基础设施相关的规格 PHS 398/2590(06/09版)页面续格式页面

Program Director/Principal Investigator (Last, First, Middle): Choy, Hak Project Summary The United States currently does not offer to its cancer patients irradiation with ions heavier than protons. There are five facilities in Asia and two in Europe that currently treat patients with nuclei of carbon ions, many of them contributing to clinical trials to explore every advantage of heavy ion therapy. UT Southwestern created a three phase proposal to construct a tri-modality Texas Center for Advanced Radiation Therapy including a proton therapy (phase 1), a photon therapy (phase 2) and a heavier ion therapy (phase 3) facility. Phase 1 is already under construction, phase 2 is also funded and at a stage of architectural designing. Phase 3 is being planned. The goal of this pilot project is to identify the potential research questions associated with the use of charged particles in radio therapy and to determine the design parameters and specifications for the research beam line and related infrastructure to address these questions. We plan to achieve this goal via a rigorous, scientific, comprehensive and peer-reviewed approach as described with three specific aims: 1) Commission two task groups charged with developing a comprehensive analysis of the questions associated with the use of the charged particle therapy and with designing the specifications for the necessary components of beam line and infrastructure; 2) Determine the potential research scope of the National Particle Research Center; 3) Develop specifications related to the research beam-line, facility, and infrastructure PHS 398/2590 (Rev. 06/09) Page Continuation Format Page