Determination of Research Needs and Specifications of The Research Beam Line and Related Infrastructure

确定研究需求和研究光束线及相关基础设施的规格

基本信息

批准号：
8811781
负责人：
Steve Bin Jiang
金额：
$ 16.46万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-10 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8811781
关键词：
Address Asia Attention Basic Science Cancer Patient Carbon ion Cell Nucleus Characteristics Charge Clinical Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Communities Development Equipment Europe Facility Designs Funding Future Goals Heavy Ions Institution International Ions Medical Methods Mind Mission Modality Outcome Patients Peer Review Phase Phase III Clinical Trials Photons Physics Pilot Projects Preparation Principal Investigator Protons Radiation Radiation therapy Radiobiology Research Research Infrastructure Research Personnel Resources Running Solutions Specific qualifier value Staging Texas Therapeutic Therapeutic Studies Time Translational Research United States architectural drawings base cancer therapy design interest irradiation meetings particle particle therapy programs proton therapy research and development research study therapy design

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Choy, Hak Project Summary The United States currently does not offer to its cancer patients irradiation with ions heavier than protons. There are five facilities in Asia and two in Europe that currently treat patients with nuclei of carbon ions, many of them contributing to clinical trials to explore every advantage of heavy ion therapy. UT Southwestern created a three phase proposal to construct a tri-modality Texas Center for Advanced Radiation Therapy including a proton therapy (phase 1), a photon therapy (phase 2) and a heavier ion therapy (phase 3) facility. Phase 1 is already under construction, phase 2 is also funded and at a stage of architectural designing. Phase 3 is being planned. The goal of this pilot project is to identify the potential research questions associated with the use of charged particles in radio therapy and to determine the design parameters and specifications for the research beam line and related infrastructure to address these questions. We plan to achieve this goal via a rigorous, scientific, comprehensive and peer-reviewed approach as described with three specific aims: 1) Commission two task groups charged with developing a comprehensive analysis of the questions associated with the use of the charged particle therapy and with designing the specifications for the necessary components of beam line and infrastructure; 2) Determine the potential research scope of the National Particle Research Center; 3) Develop specifications related to the research beam-line, facility, and infrastructure PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

计划总监/首席调查员（最后，第一，中间）：Choy，Hak 项目摘要目前，美国不提供比质子重的离子辐射的癌症患者。那里是亚洲的五个设施，目前在欧洲的两个设施治疗碳离子核的患者，其中许多促进临床试验以探索重离子疗法的所有优势。 UT西南创建了三个构建德克萨斯州晚期放射治疗中心的相位建议，包括质子治疗（第1阶段），光子治疗（第2阶段）和较重的离子治疗（第3阶段）设施。第1阶段已经在建设中，第2阶段也是资助的，并且处于建筑设计的阶段。正在计划第3阶段。该试点项目的目的是确定与使用相关的潜在研究问题无线电治疗中的颗粒并确定研究梁系的设计参数和规格和相关的基础设施以解决这些问题。我们计划通过严格，科学的，如三个特定目的所述，全面且同行评审的方法：1）委托两项任务负责对与使用相关的问题进行全面分析的团体带电的粒子疗法，并设计针对光束线的必要组成部分的规格和基础设施; 2）确定国家粒子研究中心的潜在研究范围； 3）发展与研究梁线，设施和基础设施有关的规格 PHS 398/2590（修订版06/09）页面延续格式页面