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Determination of Research Needs and Specifications of The Research Beam Line and Related Infrastructure

确定研究需求和研究光束线及相关基础设施的规格

基本信息

批准号：
8811781
负责人：
Steve Bin Jiang
金额：
$ 16.46万
依托单位：
UT SOUTHWESTERN MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2015
资助国家：
美国
起止时间：
2015-02-10 至 2017-01-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8811781
关键词：
Address Asia Attention Basic Science Cancer Patient Carbon ion Cell Nucleus Characteristics Charge Clinical Clinical Research Clinical Sciences Clinical Treatment Clinical Trials Communities Development Equipment Europe Facility Designs Funding Future Goals Heavy Ions Institution International Ions Medical Methods Mind Mission Modality Outcome Patients Peer Review Phase Phase III Clinical Trials Photons Physics Pilot Projects Preparation Principal Investigator Protons Radiation Radiation therapy Radiobiology Research Research Infrastructure Research Personnel Resources Running Solutions Specific qualifier value Staging Texas Therapeutic Therapeutic Studies Time Translational Research United States architectural drawings base cancer therapy design interest irradiation meetings particle particle therapy programs proton therapy research and development research study therapy design

项目摘要

Program Director/Principal Investigator (Last, First, Middle): Choy, Hak Project Summary The United States currently does not offer to its cancer patients irradiation with ions heavier than protons. There are five facilities in Asia and two in Europe that currently treat patients with nuclei of carbon ions, many of them contributing to clinical trials to explore every advantage of heavy ion therapy. UT Southwestern created a three phase proposal to construct a tri-modality Texas Center for Advanced Radiation Therapy including a proton therapy (phase 1), a photon therapy (phase 2) and a heavier ion therapy (phase 3) facility. Phase 1 is already under construction, phase 2 is also funded and at a stage of architectural designing. Phase 3 is being planned. The goal of this pilot project is to identify the potential research questions associated with the use of charged particles in radio therapy and to determine the design parameters and specifications for the research beam line and related infrastructure to address these questions. We plan to achieve this goal via a rigorous, scientific, comprehensive and peer-reviewed approach as described with three specific aims: 1) Commission two task groups charged with developing a comprehensive analysis of the questions associated with the use of the charged particle therapy and with designing the specifications for the necessary components of beam line and infrastructure; 2) Determine the potential research scope of the National Particle Research Center; 3) Develop specifications related to the research beam-line, facility, and infrastructure PHS 398/2590 (Rev. 06/09) Page Continuation Format Page

项目总监/主要研究者（最后，第一，中间）：Choy，Hak 项目摘要美国目前不向其癌症患者提供比质子重的离子辐照。那里目前，亚洲有五个设施，欧洲有两个设施，治疗碳离子核患者，其中许多人致力于临床试验，探索重离子治疗的每一个优点。西南大学创造了一个三一个阶段的建议，以建立一个三模态得克萨斯州中心的先进放射治疗，包括质子一个治疗（第一阶段）、一个光子治疗（第二阶段）和一个重离子治疗（第三阶段）设施。第一阶段已经第二阶段正在施工，也已获得资金，正处于建筑设计阶段。第三阶段正在规划中。该试验项目的目标是确定与使用带电的放射治疗中的粒子并确定研究束线的设计参数和规格以及相关的基础设施来解决这些问题。我们计划通过一个严格的，科学的，一个全面和同行审查的方法，如所述，有三个具体目标：1）委员会两项任务负责全面分析与使用《公约》有关的问题的小组带电粒子治疗和设计束线的必要组件的规格，基础设施; 2）确定国家粒子研究中心的潜在研究范围; 3）开发与研究光束线、设施和基础设施相关的规范 PHS 398/2590（Rev.06/09）