Ped Endocrine Fellowship Training in Diabetes Research

Ped 糖尿病研究内分泌奖学金培训

• 批准号: 6930328
• 负责人: CHARLES ALFRED STANLEY
• 金额: $ 19万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6930328
• 关键词: Ped; Endocrine; Fellowship; Training; Diabetes

DESCRIPTION (provided by applicant): The long-term goal of this Research Training Program is to develop a new generation of pediatric endocrinologists who will be equipped to carry out innovative and scientifically rigorous patient-oriented and laboratory-based research related to diabetes mellitus in children for this new 21st Century. One of the needs for this Program is the critical shortage of academic pediatric endocrinologists in diabetes research which has been emphasized by the organizations such as the American Diabetes Association, the Juvenile Diabetes Research Foundation, and the Pediatric Academic Societies. In addition, the Program recognizes the important new opportunities for advancing diabetes research in children provided by such recent scientific advances as the Human Genome Project and the successes in islet transplantation and production of biomechanical and bio-engineered islets. The Program will support Trainees during up to 2 years of research training at the fellowship level. The Training faculty includes 19 scientific mentors from the Children's Hospital and the U Penn School of Medicine who have outstanding credentials and active research programs and training records. These mentors will supervise Trainees' in basic laboratory research and/or patient-oriented research projects related to diabetes in children. Research opportunities will include three major areas of basic research 1) Signal Transduction: Mechanisms of Hormone Action; 2) Regulation of Pancreatic beta-cell Function and Development; and 3) Genetic Approaches to Diabetes and Endocrine Diseases. Patient-oriented research opportunities will include the areas of 1) Islet Immunology, Transplantation, and Regulation; 2) Obesity and Insulin Resistance, 3) Diabetes Complications; and 4) Diabetes Epidemiology and Biostatistics. The Program includes training in all aspects of research, including biostatistics, bioethics, molecular biology, etc. The Program is strongly supported by access to a superb range of institutional resources, including the CHOP GCRC and the UPenn DERC. Request is made for 3 Trainee slots in this Program each year.

描述（由申请人提供）： 该研究培训计划的长期目标是开发新一代的儿科内分泌学家，他们将有能力在这21世纪的儿童中进行与糖尿病有关的创新和科学严格的，以患者为导向的和实验室的研究。该计划的需求之一是糖尿病研究中学术儿科内分泌学家的严重短缺，这是由美国糖尿病协会，少年糖尿病研究基金会和儿科学术社会等组织强调的。此外，该计划还认识到由人类基因组项目以及胰岛移植和生物工程胰岛的胰岛移植和生产中的成功提供的最新科学进步提供的糖尿病研究的重要新机会。该计划将在奖学金水平的最多2年的研究培训期间为受训者提供支持。培训学院包括来自儿童医院的19名科学导师和U Penn医学院，他们拥有出色的证书和活跃的研究计划和培训记录。这些导师将在基础实验室研究和/或与儿童糖尿病有关的研究项目中监督受训者。研究机会将包括基础研究的三个主要领域1）信号转导：激素作用的机制； 2）调节胰腺β细胞功能和发育； 3）糖尿病和内分泌疾病的遗传方法。面向患者的研究机会将包括1）胰岛免疫学，移植和调节； 2）肥胖和胰岛素抵抗，3）糖尿病并发症； 4）糖尿病流行病学和生物统计学。该计划包括在研究的各个方面进行培训，包括生物统计学，生物伦理学，分子生物学等。该计划可以通过获得精湛的机构资源（包括Chop GCRC和Upenn Derc）的优势来支持该计划。每年在此计划中提出3个学员插槽的要求。