Race/Socioeconomic Area Characteristics & Cancer-Detroit

种族/社会经济区域特征

• 批准号: 6951834
• 负责人: ELLEN M VELIE
• 金额: $ 7.55万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-22 至 2007-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6951834
• 关键词: African American; behavioral /social science research tag; cancer registry /resource; cancer risk; caucasian American; clinical research; human data; neoplasm /cancer epidemiology; racial /ethnic difference; socioeconomics; socioenvironment; statistics /biometry

DESCRIPTION (provided by applicant): The overall objective of the proposed study is to provide a better understanding of the joint effects of racial and socioeconomic characteristics of census tracts of residence on cancer incidence rates. We propose to examine these associations with cancer incidence rates at five sites (lung/bronchus, breast, prostate, colon/rectum, and cervix) in Black and White men and women in the Detroit Metropolitan Area, 1973-2002. First, census tracts of residence will be considered a proxy for individual measures of socioeconomic position and defined by the following characteristics of census tracts of residence: (i) percent poverty, (ii) the Darden and Kamel index, 2000 and (iii) a modified Krieger Socioeconomic Position (SEP) index, 2002. Next, we consider area-based characteristics of census tracts of residence and examine the association between racial and socioeconomic segregation (including concentration, centralization and clustering) and cancer incidence rates. Information on race and cancer status will be obtained from the SEER (Surveillance, Epidemiology and End Results) Detroit Metropolitan Area cancer registry, which is ideal for these analyses because it has one the highest percentages of Blacks, compared to other SEER registries. Information on characteristics of cancer patients' residences have been geocoded to identify their census tract of residence and characteristics of these census tracts will be identified through the U.S. Census of Population and Housing for the Detroit Metropolitan Area for 1970-2000. Information on the denominator populations residing in the Detroit Metropolitan Area will also be obtained from the U.S.1970-2000 Census. Cancer incidence rates will be calculated using Poisson regression, adjusted for age and examined within strata of gender, race, and five-year time intervals between 1973-2002. Investigating the association between race, SEP, and segregation, may provide insight into disparities in cancer incidence, point to more specific etiologic hypotheses for cancer incidence, and identify target populations for prevention.

描述（由申请人提供）： 拟议研究的总体目标是更好地了解人口普查居住区的种族和社会经济特征对癌症发病率的联合影响。我们建议检查1973-2002年底特律大都会区黑人和白色男性和女性五个部位（肺/支气管、乳腺、前列腺、结肠/直肠和宫颈）癌症发病率与这些相关性。首先，居住地普查区将被视为社会经济地位个别衡量标准的替代物，并由居住地普查区的下列特征界定：㈠贫困百分比，㈡ 2000年达登和卡迈勒指数，㈢ 2002年经修改的克里格社会经济地位指数。接下来，我们考虑了基于区域的居住人口普查区的特征，并研究了种族和社会经济隔离（包括集中，集中和集群）与癌症发病率之间的关联。关于种族和癌症状态的信息将从SEER（监测、流行病学和最终结果）底特律大都会区癌症登记处获得，该登记处非常适合这些分析，因为与其他SEER登记处相比，该登记处的黑人比例最高。关于癌症患者居住地特征的信息已被地理编码，以确定其居住地的普查区域，这些普查区域的特征将通过1970-2000年美国底特律大都会区人口和住房普查来确定。关于居住在底特律大都会区的分母人口的信息也将从美国1970 -2000年人口普查中获得。癌症发病率将使用泊松回归计算，根据年龄进行调整，并在1973-2002年期间按性别、种族和5年时间间隔分层进行检查。调查种族、SEP和种族隔离之间的关系，可以深入了解癌症发病率的差异，指出癌症发病率的更具体的病因学假设，并确定预防的目标人群。