A Population Based Study of Birth Characteristics and Maternal Breast Cancer

出生特征和孕产妇乳腺癌的人群研究

• 批准号: 7261799
• 负责人: ELLEN M VELIE
• 金额: $ 7.55万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-08-08 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7261799
• 关键词: Age; Age-Years; Biological; Birth; Birth Certificates; Case-Control Studies; Characteristics; Data; Educational Background; Educational workshop; Environment; Estrogens; Etiology; Event; Fetal Growth; Fetal Growth Retardation; First Births; Gestational Age; Growth Factor; Heterogeneity; Hormonal; Hormones; Human Chorionic Gonadotropin; Incidence; Insulin-Like Growth Factor I; Knowledge; Light; Link; Long-Term Effects; Michigan; Modification; Multiple Birth Offspring; Not Hispanic or Latino; Personal Satisfaction; Population; Population Study; Pregnancy; Premature Birth; Premenopause; Progesterone; Purpose; Race; Rate; Registries; Risk; Role; Sample Size; Serum; Socioeconomic Status; Somatomedins; Summary Reports; Time; Twin Multiple Birth; Week; Woman; base; breast cancer diagnosis; cancer risk; high school; insight; interest; malignant breast neoplasm; neoplasm registry; reproductive

DESCRIPTION (provided by applicant): Pregnancy has been shown to have both a short- and long-term effect on breast cancer risk; a short-term (3-5 year) increase in breast cancer risk is followed by a long-term (> 10 year) reduction in risk and both associations appear to be modified by age at delivery. Hormonal factors have also long been implicated in the etiology of breast cancer. Though exact biological mechanisms are unknown, the short-term increase in breast cancer risk associated with pregnancy has been hypothesized to be attributable to the substantially elevated levels of multiple hormones (e.g., estrogens, progesterone, human chorionic gonadotropin (HCG), and insulin- like growth factor (IGF-1) seen during pregnancy. Offspring birth characteristics (e.g., preterm delivery or low or high fetal growth) may well be associated with an altered hormonal environment during pregnancy and influence maternal breast cancer risk, but associations between offspring birth characteristics and breast cancer risk are not well established. The overall objective of this study is to examine the associations between offspring birth characteristics that have inconsistently been implicated in breast cancer risk and premenopausal breast cancer (e.g., 50 years of age or less). Specifically, we will examine the association between preterm (< 37 weeks gestation) and very preterm delivery (< 32 weeks gestation), fetal growth (birthweight-for-gestational age), multiple births and breast cancer risk. Since age at first birth and subsequent deliveries, and time since birth, have been shown to influence the effect of pregnancy on maternal breast cancer risk, we will also examine potential modification of associations between offspring birth characteristics and breast cancer risk by age at first delivery (= 30, > 30 years), age at delivery of each subsequent pregnancy (= 30, > 30), and time since delivery at breast cancer diagnosis (< 5 years, = 5 years). Breast cancer incidence has also been shown to vary by race and socioeconomic status; since these factors may also modify our exposures of interest, we will examine potential effect modification of associations between offspring birth characteristics and breast cancer risk by race (Non-Hispanic White, Non-Hispanic Black), and socioeconomic status (based on age- appropriate education level at first delivery). We propose to conduct a registry-linked, population-based, case- control study using Michigan maternally-linked birth certificate data (1978-2003) and the Michigan state-wide cancer registry data (1985-2005) among parous Non-Hispanic Black and Non-Hispanic White women 50 years of age or less to examine these associations. Results from this study of the association between birth characteristics that may reflect an altered maternal hormonal milieu during pregnancy and breast cancer, may provide insight into potential biological mechanisms for the role of pregnancy in premenopausal breast cancer risk. Given the heterogeneity of our study population, and ample sample size, results may also shed light on observed differences in incidence rates of premenopausal breast cancer among Black and White women and women of different socioeconomic status.

描述（由申请人提供）： 研究表明，怀孕对乳腺癌风险有短期和长期影响;乳腺癌风险短期（3-5年）增加后，风险长期（> 10年）降低，这两种关联似乎都因分娩时的年龄而改变。长期以来，激素因素也被认为与乳腺癌的病因有关。虽然确切的生物学机制尚不清楚，但与怀孕相关的乳腺癌风险的短期增加被假设可归因于多种激素（例如，雌激素、孕酮、人绒毛膜促性腺激素（HCG）和胰岛素样生长因子（IGF-1）。后代出生特征（例如，早产或胎儿生长缓慢或过快）可能与怀孕期间荷尔蒙环境的改变有关，并影响母亲患乳腺癌的风险，但后代出生特征与乳腺癌风险之间的关系尚未得到很好的确定。本研究的总体目标是检查与乳腺癌风险不一致的后代出生特征与绝经前乳腺癌之间的关联（例如，50岁或以下）。具体来说，我们将研究早产（< 37周妊娠）和极早产（< 32周妊娠），胎儿生长（胎龄出生体重），多胞胎和乳腺癌风险之间的关系。由于首次分娩和随后分娩的年龄以及出生后的时间已被证明会影响妊娠对母体乳腺癌风险的影响，因此我们还将研究首次分娩年龄对后代出生特征和乳腺癌风险之间关联的潜在修改（= 30，> 30岁）、每次后续妊娠分娩时的年龄（= 30，> 30）和自分娩至乳腺癌诊断的时间（< 5年，= 5年）。乳腺癌发病率也因种族和社会经济地位而异;由于这些因素也可能改变我们关注的暴露量，我们将按种族（非西班牙裔白色、非西班牙裔黑人）和社会经济地位（基于首次分娩时的适龄教育水平）检查后代出生特征与乳腺癌风险之间相关性的潜在效应改变。我们建议在50岁或以下的非西班牙裔黑人和非西班牙裔白色妇女中，使用密歇根州与母亲相关的出生证明数据（1978-2003年）和密歇根州范围内的癌症登记数据（1985-2005年）进行一项登记相关的、基于人群的病例对照研究，以检查这些关联。这项研究的结果可能反映了怀孕期间母体激素环境的改变与乳腺癌之间的相关性，可能为妊娠在绝经前乳腺癌风险中的作用提供潜在的生物学机制。考虑到我们研究人群的异质性和充足的样本量，结果也可能揭示黑人和白色妇女以及不同社会经济地位妇女绝经前乳腺癌发病率的差异。