CORE--ANIMAL BREEDING AND SURGICAL FACILITY

核心——动物饲养和手术设施

• 批准号: 6909162
• 负责人: THOMAS M COFFMAN
• 金额: $ 10.99万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6909162
• 关键词: animal breeding; animal colony; biomedical facility; heart transplantation; kidney transplantation; laboratory mouse; microsurgery; transplant rejection

The Microsurgical Core (Core B) plays a central role in the strategies for achieving the specific objectives of this Program. All projects depend on the technical expertise of the Core B facility and this technical expertise is the foundation for the Program. As this Program was originally organized, it became obvious to all the investigators that in order for them to pursue studies in the area of renal transplantation, each would have to train one or two transplant technicians, equip surgical stations, and maintain populations of animals independently. By combining efforts in a Program Project that provided a core laboratory for maintaining animals and performing transplant surgery, a tremendous amount of money and effort could be saved. The numerous ongoing collaborations, the enthusiasm for the pursuit of studies in the area of transplantation and the legitimate need for the development of a Core facility provided the impetus for the original development of this Program Project. These circumstances have persisted and in fact the enthusiasm and demand for the Core services have steadily increased. The primary role of the Microsurgical Core facility continues to be providing mouse transplants to Project investigators. For the current proposal, the core will provide both kidney and heart transplants. This Core also provides capabilities for measuring renal transplant function as specified within the individual proposals. The techniques for transplantation and the experimental utilization of transplanted animals is described in detail in the individual Project proposals.

显微外科核心（核心B）在实现本计划具体目标的战略中发挥着核心作用。所有项目都依赖于核心B设施的技术专长，而这种技术专长是该计划的基础。由于该计划最初的组织，所有研究人员都清楚，为了让他们在肾移植领域进行研究，每个人都必须培训一两名移植技术人员，配备手术站，并独立维持动物种群。通过在一个计划项目中的共同努力，提供了一个核心实验室来维持动物和进行移植手术，可以节省大量的金钱和精力。的 许多正在进行的合作，对移植领域研究的热情以及发展核心设施的合理需求为该计划项目的最初发展提供了动力。这些情况一直存在，事实上，对核心服务的热情和需求稳步上升。 显微外科核心设施的主要作用仍然是为项目研究人员提供小鼠移植。对于目前的建议，核心将提供肾脏和心脏移植。该核心还提供了测量肾移植功能的能力，如个别提案中所规定的。移植技术和移植动物的实验利用在个别项目建议书中有详细说明。