Administrative Core

行政核心

• 批准号: 8433280
• 负责人: THOMAS M COFFMAN
• 金额: $ 18.05万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8433280
• 关键词: Address; Administrator; Area; Basic Science; Cardiovascular Diseases; Cause of Death; Chronic Kidney Failure; Clinical; Clinical Sciences; Development; Economic Factors; Education; Eligibility Determination; End stage renal failure; Feasibility Studies; Foundations; Funding; Future; Grant; Hypertension; Individual; Kidney; Kidney Diseases; Link; Modification; Patients; Performance; Pilot Projects; Platelet Factor 4; Program Reviews; Research; Research Personnel; Research Support; Resource Allocation; Resources; Services; Site Visit; Technology; Translating; Vision; base; cardiovascular risk factor; clinical practice; design; investigator training; member; new technology; operation; programs; success

Exaggerated cardiovascular risk is arguably the most pressing clinical problem facing nephrologists and their patients. The causes of this preponderance of cardiovascular disease in patients with kidney disease are not clear, but hypertension amplifies cardiovascular risk and promotes progression of chronic kidney disease irrespective of the primary cause. Accordingly, the major objective of the George M. O'Brien Kidney Research Core Center at Duke is to promote and support research into understanding the unique links between the kidney, cardiovascular disease, and hypertension. The Administrative Core will be responsible for the overall administrative oversight for the Center. The Director, Dr. Thomas Coffman, will have primary responsibility for coordinating day-to-day operations. He will be assisted by the Associate Director and Center Administrator. Primary governance of the Center will be provided by an Executive Committee consisting of the Center Director, Associate Director, the Core Directors, Chair of the Pilot and Feasibility Program, and Coordinator of the Enrichment Program. The Specific Aims of the Administrative Core are: (1) Provide general oversight of Core operations and performance; (2) Review and assign priorities to proposals for use of Core services, including: (a) establishing investigator eligibility, (b) determining scientific priorities, and (c) determining overall priorities for use of Core services; (3) Implement modifications in Core services based on development of new technologies or services, sub-optimal performance of existing technologies or services, and/or economic factors; (4) Promote interactions between the cores with an emphasis on transitioning discoveries from basic discovery projects to clinical and translational programs, (5) Assessing adequacy of resource allocation; (6) Oversight for pilot and feasibility studies to explore new areas of research relevant to the kidney in cardiovascular diseases serving as a foundation for other external funding. These funds will support new investigators, and will be used to entice senior investigators to address key issues in this thematic area; and (7) Develop education programs designed to highlight the importance of the interrelationship of kidney and cardiovascular disease, to inform Center investigators of the latest advances in relevant research, and to train investigators in clinical and basic science approaches to advance research.

夸张的心血管风险可以说是肾脏病医生及其患者面临的最紧迫的临床问题。肾脏疾病患者中这种心血管疾病优势的原因尚不清楚，但是高血压会扩大心血管风险，并促进慢性肾脏疾病的进展，而与主要原因无关。因此，杜克大学乔治·奥布莱恩肾脏研究核心中心的主要目标是促进和支持研究，以了解肾脏，心血管疾病和高血压之间的独特联系。行政核心将负责该中心的整体行政监督。董事托马斯·科夫曼（Thomas Coffman）博士将负责协调日常运营。他将得到副主任兼中心管理员的协助。该中心的主要治理将由执行委员会提供，由中心主任，副主任，核心主任，试点和可行性计划主席以及Enrichment计划的协调员提供。行政核心的具体目的是：（1）对核心操作和绩效提供一般监督； （2）审查并将优先级分配给使用核心服务的建议，包括：（a）建立研究人员资格，（b）确定科学优先级，以及（c）确定使用核心服务的总体优先级； （3）基于新技术或服务的开发，现有技术或服务的次优绩效以及/或经济因素实施核心服务的修改； （4）促进核心之间的互动，重点是从基本发现项目到临床和转化计划的过渡发现，（5）评估资源分配的充分性； （6）对试点和可行性研究的监督，以探讨与心血管疾病中肾脏有关的新研究领域，这是其他外部资金的基础。这些资金将支持新的调查人员，并将用于吸引高级调查人员解决这个主题领域的关键问题； （7）制定旨在强调肾脏和心血管疾病相互关系的重要性，以告知中心研究人员相关研究的最新进展，并培训研究人员采用临床和基础科学方法进行进步研究。