George M. O'Brien Kidney Research Core Centers

项目摘要(请参阅说明)：合成 心血管疾病是肾病患者的主要死因。肾脏疾病患者中心血管疾病占多数的原因尚不清楚。 高血压在慢性肾脏病(CKD)患者中也非常普遍，这是美国终末期肾脏疾病的第二大常见原因。无论主要原因是什么，血压升高都会增加心血管风险，促进慢性肾脏病的进展。 由于慢性肾脏病患者更有可能死于心血管疾病，而不是需要肾脏替代治疗，因此夸大的心血管风险可以说是肾科医生和他们的患者面临的最紧迫的临床问题。因此，杜克大学乔治·M·奥布莱恩肾脏研究核心中心的主要目标是促进和支持研究，以了解肾脏、心血管疾病和高血压之间的独特联系。我们认识到，这一领域的进展将需要多学科的研究人员团队，他们在临床和基础科学的一系列学科中具有广泛的专业知识。为此，我们中心将动员唯一的 杜克大学医学中心的资源来解决这个令人望而生畏的临床问题，包括。 利用我们雄厚的国际研究基础，我们将通过以下具体目标实现我们的目标：(1)制定旨在强调肾脏和心血管疾病相互关系的重要性的教育计划，向中心研究人员通报相关研究的最新进展，并培训研究人员在临床和基础科学方法方面推进研究。(2)支持试点和可行性研究，以探索与心血管疾病中肾脏相关的新研究领域，作为其他外部资金的基础。(三)建立 支持基础发现研究的动物模型核心。(4)建立肾脏遗传学核心，为了解肾脏和高血压等心血管疾病的遗传学提供智力和技术支持。(5)建立临床/翻译核心，以促进和促进关于慢性肾脏病、高血压和心血管疾病之间相互关系的临床和翻译研究。

PROJECT SUMMARY (See instructions): Composite Cardiovascular disease is the major cause of death for patients with kidney disease. The causes of this preponderance of cardiovascular disease in patients with kidney disease are not clear. Hypertension is also highly prevalent in patients with chronic kidney disease (CKD), representing the second most common cause of end-stage renal disease in the US. Elevated blood pressure amplifies cardiovascular risk and promotes progression of CKD irrespective of the primary cause. Since a patient with CKD is more likely to die from cardiovascular disease than to require renal replacement therapy, exaggerated cardiovascular risk is arguably the most pressing clinical problem facing nephrologists and their patients. Accordingly, the major objective of the George M. OBrien Kidney Research Core Center at Duke is to promote and support research into understanding the unique links between the kidney, cardiovascular disease, and hypertension. We recognize that progress in this area will require multi-disciplinary teams of investigators with broad expertise across a range of disciplines in the clinical and basic sciences. To this end, our Center will mobilize unique resources at Duke University Medical Center to bear upon this daunting clinical problem including. Taking advantage of our robust international research base, we will accomplish our objective through the following specific aims: (1) Develop education programs designed to highlight the importance of the interrelationship of kidney and cardiovascular disease, to inform Center investigators of the latest advances in relevant research, and to train investigators in clinical and basic science approaches to advance research. (2) Support pilot and feasibility studies to explore new areas of research relevant to the kidney in cardiovascular diseases serving as a foundation for other external funding. (3) Establish an Animal Models Core to support basic discovery research. (4) Establish a Renal Genetics Core to provide intellectual and technical support for understanding the genetics of kidney and cardiovascular diseases including hypertension. (5) Establish a Clinical/Translational Core to foster and facilitate clinical and translational research on the inter-relationships among CKD, hypertension, and cardiovascular disease.