How do birds contribute to the spread of antimicrobial resistant microorganisms?

鸟类如何促进耐药微生物的传播？

• 批准号: 2592884
• 金额: --
• 依托单位: Bangor University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2592884
• 关键词: How; do; birds; contribute; spread

The emergence and spread of antimicrobial resistance genes (AMR) amongst pathogenic microorganisms is one of the greatest health issues of this century. Over-use of antibiotics in treating humans and livestock are both well established as sources of AMR but a third source of AMR comes from the natural environment. In particular, it has been found in the gut flora of wild birds most notably the Larus gulls, including multidrug resistant strains, but the implications of AMR in birds for human health and the spread of AMR remains unknown. Birds provide a particular challenge in the dissemination of AMR bacteria because some of the species known to carry AMR bacteria migrate, often between continents. Gulls are also of particular interest as they have become increasingly associated with human sites in their foraging patterns. With this in mind, this project will investigate the role of gull movement behaviour in the potential spread and maintenance of AMR using a combination of a large data set of GPS tracks collected by project partners the BTO in combination with sampling at the sites where tracking data was obtained. The key aim is to determine the relative roles and impact of foraging and migration on spread and maintenance of AMR and potential links to human health.

致病微生物中抗菌抗性基因（AMR）的出现和传播是本世纪最大的健康问题之一。抗生素在治疗人类和牲畜方面的过度使用都是AMR的来源，但AMR的第三个来源来自自然环境。特别是，它是在野生鸟类的肠道菌群中发现的，最著名的是拉鲁斯海鸥，包括抗多药菌株，但是AMR在鸟类对人类健康中的含义和AMR的传播仍然未知。鸟类在传播AMR细菌方面提供了一个特殊的挑战，因为一些已知的携带AMR细菌的物种通常在大陆之间迁移。海鸥在觅食模式中与人类遗址越来越相关，因此鸥也特别感兴趣。考虑到这一点，该项目将使用Project Partners收集的大量GPS轨道的组合来研究Gull运动行为在AMR潜在扩散和维持AMR中的作用。关键目的是确定觅食和迁移对AMR的传播和维持以及与人类健康的潜在联系的相对作用和影响。