Rates/Risk Factors for Endophthalmitis After Cataract Su

白内障术后眼内炎的发生率/危险因素

• 批准号: 6958970
• 负责人: EMILY W GOWER
• 金额: $ 70.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-30 至 2008-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6958970
• 关键词: cardiovascular disorder risk; cataract surgery; clinical research; epidemiology; human data; human old age (65+); patient oriented research; postoperative complications; uveitis

DESCRIPTION (provided by applicant): Cataract surgery, the most commonly performed procedure in the United States, has undergone substantial technologic improvements over the past 20 years. One would anticipate that the smaller wounds, shorter operative time, and more rapid visual and ambulatory recovery would be associated with a reduction in the rate of postoperative endophthalmitis, perhaps the most significant operative complication. We show preliminary research that strongly suggests that the rate has been increasing over the past decade and that age and black race are important risk factors. The literature on the epidemiology of endophthalmitis is largely limited to small and regional studies. These suggest that surgical factors such as the location (ie. corneal vs scleral) and closure (ie. use vs non-use of stitch) of the wound may be important as well as intensity and timing of perioperative antibiotic use. We propose to ascertain nationally representative rates of acute endopthalmitis following cataract surgery by identifying and verifying cases of endophthalmitis ascertained from Medicare data files. We will then try to identify patient and surgical risk factors for endopthalmitis in a population-based case-control study by examining potential risk factors in 392 cases and 1176 controls drawn from the same Medicare base. The investigators hope to identify factors that can be modified to lower the rate of endopthalmitis and to provide information that would facilitate planning for future interventional trials.

描述（由申请人提供）：白内障手术是美国最常见的手术，在过去20年中经历了实质性的技术改进。可以预期，较小的伤口、较短的手术时间以及更快的视力和行走恢复将与术后眼内炎（可能是最重要的手术并发症）的发生率降低相关。我们显示初步研究强烈表明，在过去十年中，该比率一直在增加，年龄和黑人种族是重要的风险因素。关于眼内炎流行病学的文献主要局限于小型和区域性研究。这些表明，手术因素，如位置（即。角膜对巩膜）和闭合（即，使用与不使用缝线）以及围手术期抗生素使用的强度和时间可能很重要。我们建议通过识别和验证从医疗保险数据文件中确定的眼内炎病例来确定白内障手术后急性眼内炎的全国代表性发病率。然后，我们将尝试在一项基于人群的病例对照研究中，通过检查来自同一医疗保险基地的392例病例和1176例对照的潜在风险因素，确定眼内炎的患者和手术风险因素。研究人员希望确定可以修改以降低眼内炎发生率的因素，并提供有助于规划未来干预性试验的信息。