Repulsion in Spatial Population Models

空间人口模型中的排斥

• 批准号: 2595475
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2595475
• 关键词: Repulsion; Spatial; Population; Models

Mathematical population genetics is the development and subsequent study of models that describe the evolution of a population's genetic composition due to effcts such as natural selection, mutation, and random genetic drift, with the goal of explaining and analysing phenomena like adaption and speciation. Finding and understanding such models gives fundamental insights in the driving forces of evolution, and can be used to answer questions about past and future of humans and other species. For example, Speidel et al. (2019) have recently used data from the 1000 Genomes Project to make statistical inferences about thegenealogical history of human populations on dfferent continents, including, amongst other things, predictions about population sizes up to several million years in the past.The earliest models-developed by Wright (1931) and Fisher (1930, 1958)-regard a population as an abstract collection of genes and impose rules on how they are passed on between generations. Although successful at describing small, spatially contained populations, these models fail to predict evolutionary phenomena that cannot be explained without taking the spatial distribution of a population into account: Already the simple fact that offspring are born at the location of their parent gives the spread of mutations and genetic adaption a spatial inertness. This becomes especially impactful when a population is spread over a large area, where this effect may cause speciation-the formation of different subspecies.One of the key contributions leading to the modern study of spatial population models was made by Watanabe (1968) and Dawson (1977, 1979), who introduced what we now call superprocesses, a model prototype that describes the evolution of a spatially evolving population in the limit of large sizes. One of the assumptions underlying the original model is that individuals move and reproduce independently of each other, which is convenient mathematically, but unrealistic. One effect is that there is no mechanism in place that stops large populations from growing further, leading to indefinitely growing population sizes andthe frequent formation of so-called clumps of huge population density. In real populations, individuals depend on common, finite resources such as food, water, and living space. Hence, in areas of high population density, individuals will have shorter living spans, reproduce less, and tend to migrate to areas of lower population density. A lot of recent effort has been on incorporating the former two effects into the superprocess model by making the expected number of offspring of an individual decrease with the local population density. The latter effect, however, has received little attention. The goal of my research is to augment the superprocess model with a drift that pushes individuals away from areas of high population density, by introducing a repelling force between individuals. I seek to understand under which assumptions this addition leads to stable population dynamics, and how its effects differ from and interplay with the aforementioned models that control reproduction depending on local population density. Furthermore, this approach forms a natural first step towards extending the superprocess model to account for different sexes, which could be achieved by having individuals of opposite and same sex respectively attract and repel each other. Studying such a model and comparing it with the original one may lead to insights into diffrences between the evolution of sexually and asexually reproducing populations, and shed light on the puzzling observed success of the former.This project falls within the EPSRC Mathematical sciences research area.

数学种群遗传学是对描述由于自然选择、突变和随机遗传漂移等影响而导致的种群遗传组成进化的模型的发展和后续研究，目的是解释和分析适应和物种形成等现象。发现和理解这样的模型可以从根本上洞察进化的驱动力，并可以用来回答关于人类和其他物种的过去和未来的问题。例如，Speidel等人。(2019)最近使用1000基因组计划的数据对不同大陆的人类种群的谱系历史做出统计推断，其中包括对过去数百万年人口规模的预测。最早的模型-由赖特(1931)和费舍尔(1930,1958)开发-将种群视为基因的抽象集合，并对它们如何在世代之间传递施加规则。尽管这些模型成功地描述了小的、空间上包含的种群，但它们未能预测如果不考虑种群的空间分布就无法解释的进化现象：后代出生在父母所在位置这一简单事实已经给突变的传播和遗传适应带来了空间惰性。当种群分布在大范围内时，这种影响变得特别重要，这种效应可能导致物种形成-不同亚种的形成。导致现代空间种群模型研究的关键贡献之一是Watanabe(1968)和Dawson(1977,1979)，他们引入了我们现在所说的超级过程，一个模型原型，描述了在大尺寸限制下空间进化的种群的演化。原始模型的基础假设之一是，个体相互独立地移动和繁殖，这在数学上是方便的，但不现实。一个影响是，没有机制阻止大量人口进一步增长，导致人口规模无限期增长，并经常形成所谓的巨大人口密度聚集区。在真实的人口中，个人依赖于共同的有限资源，如食物、水和生活空间。因此，在人口密度高的地区，个体的寿命较短，繁殖较少，并倾向于迁移到人口密度较低的地区。最近的许多努力都是为了将前两种效应纳入超级过程模型，使个人的预期后代数量随着当地人口密度的增加而减少。然而，后一种效应几乎没有受到关注。我的研究目标是通过在个人之间引入排斥力，在超过程模型中增加漂移，将个人推离人口密度较高的地区。我试图理解在哪些假设下，这一增加导致了稳定的人口动态，以及它的影响如何与前述依赖于当地人口密度控制生殖的模型不同和相互作用。此外，这种方法形成了将超过程模型扩展到考虑不同性别的自然第一步，这可以通过让异性个体和同性个体分别相互吸引和排斥来实现。研究这样的模型并将其与原始模型进行比较，可能会深入了解有性生殖种群和无性生殖种群进化之间的差异，并揭示前者令人费解的观察到的成功。该项目属于EPSRC数学科学研究领域。