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Deep learning for spatial population genetics

空间群体遗传学的深度学习

基本信息

批准号：
10464822
负责人：
Chris C Smith
金额：
$ 6.72万
依托单位：
UNIVERSITY OF OREGON
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-06-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10464822
关键词：
Anopheles Genus Anopheles gambiae Applications Grants Birth Bypass Cameroon Computational Technique Computer software DNA Data Data Set Demography Disease Management Disease Vectors Disease susceptibility Educational process of instructing Evolution Genes Genetic Genetic Models Genetic Variation Genomics Genotype Geography Goals Habitats Heterogeneity Human Impairment Individual Insecticide Resistance Insecticides Length Location Machine Learning Malaria Manuscripts Maps Medical Genetics Medicine Mentors Methodology Methods Mexico Modeling Native Americans North America Oregon Organism Output Play Ploidies Population Population Density Population Genetics Population Sizes Postdoctoral Fellow Preparation Process Public Health Recording of previous events Research Role Sample Size Sampling Shapes Structure Susceptibility Gene System Training Universities Variant computing resources deep learning deep neural network density genome wide association study genome-wide genomic data genomic variation high dimensionality indexing learning strategy open source study population symposium theories tool trait undergraduate student vector vector control

项目摘要

Project Summary/Abstract Understanding spatial genetic variation is tremendously valuable for medical genetics, understanding human population history, identifying the geographic origin of samples, and management of disease vectors. However while organisms in natural populations disperse a limited distance from their birth location, most population genetic models do not account for such genetic isolation over space, and instead treat populations as composed of discrete demes. Moreover, dispersal rate and population density often vary across the landscape due to heterogeneous environmental conditions, population structure, or simply geography. These modeling violations have real world implications, for example, in correcting genome-wide association for hidden population structure (Berg et al., 2019; Sohail et al., 2019; Battey et al. 2020a; Zaidi and Mathieson, 2020). In this proposal we aim to develop a genomics toolset for inferring spatial population genetic parameters through the use of deep learning. One strategy for dealing with geo-referenced genomic data is to train a deep neural network (DNN) to identify useful information in the data in an automated fashion. DNNs can be trained on simulated data, which bypasses the need to obtain empirical data for training. In this proposal we present the first use of DNNs for inference of spatial population genetic parameters. The proposal has three Specific Aims: 1) we will develop a method that uses DNNs to estimate spatially varying dispersal rates from geo-referenced DNA samples, 2) we will modify our deep learning tool to infer the additional demographic parameter of population density across space and 3) lastly, we will apply our method to infer dispersal rate and density in two important empirical systems for which geo-referenced genomic data are available: Anopheles gambiae, and in humans. Our approach for inferring spatial demographic processes will directly inform empirical applications such as genome wide association studies and disease vector control, as well as lay the groundwork for other spatial population genetic inquiries. The postdoctoral fellow will receive rigorous training in cutting edge computational techniques relevant to deep learning and statistical and quantitative methods in spatial population genetics. The sponsoring labs have abundant computational resources to support the proposed research. In addition, the University of Oregon houses an NSF-supported center for machine learning which will provide incredible opportunities for the fellow. Additional training will include preparation of grant proposals and first author manuscripts, presenting at conferences, advising undergraduate thesis projects, and mentored teaching in-classroom.

项目总结/文摘