TROPICAL INFECTIOUS DISEASE TRAINING GRANT

描述(由申请人提供)：巴伊亚联邦大学免疫学服务与美国和其他巴西机构合作，正在进行关于热带地方性疾病(利什曼病、血吸虫病、HTLV-1)的研究计划，旨在：1)表征对这些病原体的免疫反应，2)将免疫反应与这些疾病的临床表现联系起来，3)研究基因对疾病结果的影响，4)确定新的治疗和控制措施，以及5)确定干扰疾病结果的病原体成分。巴伊亚联邦大学过去曾利用与康奈尔大学的合作，在福格蒂赞助的培训项目中培训年轻的调查人员。虽然免疫学服务得到了研究方面的支持(包括TMRC、NIH的赠款)，但在解决实施这些项目所需的培训需求方面没有具体的支持。本提案将利用利什曼病研究中确定的需求来解决以下具体目标：1)在遗传学、疾病发病机制、临床研究和伦理等领域创造培训机会；2)向巴伊亚和巴西其他大学的其他研究人员传播培训。为了达到第一个目标，该计划强调与外国大学(康奈尔大学、爱荷华大学、约翰霍普金斯大学、宾夕法尼亚大学、剑桥大学)合作，为博士后研究员提供长期培训(共5名)，并为年轻和高级研究人员提供短期高级培训(共5名)，以满足特定领域内专业知识的具体需求。第二个目标将通过利用本国的专门知识和资源以及受过高级培训的导师来实现，以便在巴西导师的培训之后，为基础和临床免疫学、免疫疗法、分子和临床流行病学等领域的本科生、研究生、青年研究人员、医生和技术人员提供培训，以及在上述新领域提供培训。

DESCRIPTION (provided by applicant): The Immunology Service of the Federal University of Bahia has ongoing research programs on endemic tropical diseases (leishmaniasis, schistosomiasis, HTLV-1) in collaboration with US and other Brazilian institutions aimed at: 1) Characterizing the immune response to these pathogens, 2) Correlating immunological response with clinical manifestations of these diseases, 3) Studying genetic contributions to disease outcome, 4) Identifying new forms of therapy and control measures, and 5) Identifying pathogen components that interfere in disease outcome. The Federal University of Bahia has taken advantage of its collaboration with Cornell University in the past, through training of young investigators in Fogarty-sponsored Training Programs. Although the Immunology Service receives support for research (including a TMRC, NIH grant), there is no specific support for addressing training needs required to implement these projects. The present proposal will use needs identified in the studies of leishmaniasis to address the following specific aims: 1) To create training opportunities in areas such as genetics, disease pathogenesis, clinical investigation and ethics, 2) To disseminate training to other investigators from Bahia and other universities of Brazil. To address the first aim this program emphasizes collaboration with foreign universities (Cornell University, University of Iowa, Johns Hopkins, University of Pennsylvania, Cambridge University) for longterm training of post-doctoral fellows (total of 5) and short-term advanced training for young and senior investigators (total of 5) to address the specific needs in expertise within the specified areas. The second aim will be addressed by using the in-country expertise and resources and the advanced trained mentors to provide training for graduate, post-graduate students, young investigators, physicians and technicians in areas such as basic and clinical immunology, immunotherapy, molecular and clinical epidemiology, as well as in the new areas specified above after the training of the Brazilian mentors.