TRAINING GRANT IN MUCOSAL IMMUNOLOGY AND EPIDEMIOLOGY

说明：说明应用程序的广泛、长期目标和具体目标，并参考该项目与健康相关的内容。描述 简要介绍了实现这些目标的研究设计和方法。避免总结过去的成就和使用第一人称。此描述 是为了在脱离应用程序时，作为拟议工作的简明和准确的说明。如果申请获得资助，则此描述为 是，将成为公开的信息。因此，不包括专有/机密信息。请勿超出所提供的空间。 这笔培训赠款将支持母公司国际的研究和培训目标 传染病研究合作(ICIDR)奖，题为“对霍乱弧菌的免疫反应” 在ICIDR奖中，我们建议研究粘膜的这些成分 在世界上霍乱弧菌感染的地方性地区，对霍乱有保护作用的免疫反应， 并在多变量分析中将这些成分与细菌和宿主因素相关联。我们有两个主要的 外国合作者，国际疾病控制中心的一名高级免疫学家和一名高级流行病学家 孟加拉国达卡腹泻病研究(ICDDR，B)。ICDDR，B是国际公认的 腹泻病研究机构。然而，在这个机构以及在 整个孟加拉国家，培训更多的现代免疫学技术和科学家 流行病学。在这笔培训补助金中，我们建议在以下领域确定两名博士级别的卫生专业人员 孟加拉国，他们将来美国接受为期两年的培训。一名实习生将专注于 免疫学研究，将在马萨诸塞州国际和平研究所的基础研究实验室工作两年 综合医院，学习黏膜免疫技术，如酶联免疫吸附试验和抗体分泌细胞 化验、杀弧菌抗体测量，以及相关动物模型的研究。另一名实习生将专注于 关于流行病学和第一年的培训，将报读流行病学理学硕士学位 哈佛大学公共卫生学院传染病流行病学研究项目。在第二个 今年，这名个人将在孟加拉国进行现场流行病学研究，直接支持 家长ICIDR补助金的研究和培训目标，并在培训教师的共同监督下 孟加拉国和美国都是如此。此计划的候选人最初将由我们的合作者在 ICDDR，B在孟加拉国，然后将与美国的培训人员联合选拔。一个重要的 对我们决定的考虑将是个人返回孟加拉国工作的承诺 完成培训，并承诺孟加拉国的一个机构(如复员和重返社会国际委员会，B)为他们提供培训 一个职位。这笔培训赠款的目的是加强科学和公共卫生基础设施 孟加拉国并支持母公司ICIDR奖的研究目标。 演出现场(S)(组织、市、州) 马萨诸塞州波士顿马萨诸塞州总医院 哈佛公共卫生学院，波士顿，马萨诸塞州 国际腹泻病研究中心，达卡，孟加拉国 关键人员。请参阅第11页的说明。根据需要使用续页，以下面所示的格式提供所需信息。 命名项目中的组织角色 马萨诸塞州总医院医学博士斯蒂芬·B·卡尔德伍德 乔纳森·弗里曼，哈佛大学公共卫生学院医学博士 爱德华·T·瑞安，马萨诸塞州总医院医学博士 David A.Sack，医学博士，ICDDR，B Co-Pi Firdausi Qadri，ICDDR博士，B Co-Pi 赛义德·M·阿克拉穆扎曼，ICDDR博士，B Co-Pi 小灵通398(4/98版)第2页BB 在整个应用程序的底部连续编号页码。不要使用3a、3b等后缀。 NN首席调查员/项目主任(S，中)：考德伍德。史蒂芬·B。 在每个ACN打印页面和每个续页的顶部键入节目导演的姓名。(有关类型规格，请参阅第6页的说明。) 机构国家研究服务奖 (替换页面)

DESCRIPTION: State the application's broad, lonjprerm objectives and specific aims, making reference to the health relatedness of the project. Describe concisely the researchdesign and methodsfor achieving these goals. Avoid summariesof past accomplishmentsand the use of the first person. Thisdescription is meant to serve as a succinctand accuratedescriptionof the proposedwork whenseparated from the application. If the application is funded,this description,as is, will become public information. Therefore, do not include proprietary/confidential information. DO NOT EXCEEDTHE SPACE PROVIDED. This training grant would support the research and training goals of the parent International Collaborations in Infectious Disease Research (ICIDR) Award, entitled "Immune responses to V. cholerae infection in Bangladesh". In the ICIDR Award, we proposed to investigate those components of the mucosal immune response that are protective against cholera in an area of the world endemic for V.cholerae infection, and to correlate these components in a multivariate analysis with bacterial and host factors. We have two major foreign collaborators, a senior immunologist and a senior epidemiologist at the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh (ICDDR,B). The ICDDR,B is an internationally recognized facility for research in diarrheal diseases. However, there is a strong need at this institution, as well as in the country of Bangladesh overall, to train additional scientists in modern techniques of immunology and epidemiology. In this training grant, we propose to identify two doctoral level health professionals in Bangladesh, who will come to the US for training for a period of two years each. One trainee will focus on immunology research and will spend two years in the Pi's basic research laboratory at the Massachusetts General Hospital, learning mucosal immunological techniques such as ELISA and antibody-secreting cell assays, vibriocidal antibody measurements, and work with relevant animal models. The other trainee will focus on epidemiology and for the first year of training, will enroll in the Masters of Science in Epidemiology Degree program at the Harvard School of Public Health, in the Infectious Disease Epidemiology track. In the second year, this individual will do an epidemiological study in the field, in Bangladesh, in direct support of the research and training aims of the parent ICIDR grant, and under the joint supervision of the training faculty in both Bangladesh and the US. Candidates for this program will initially be identified by our collaborators at the ICDDR,B in Bangladesh and then will be jointly selected with the US training faculty. An important consideration for our decisions will be the commitment of the individuals to return to work in Bangladesh at the completion of training and the commitment of an institution in Bangladesh (such as the ICDDR,B) to give them a position. The intent of this training grant is to strengthen the scientific and public health infrastructure in Bangladesh and support the research aims of the parent ICIDR Award. PERFORMANCE SITE(S) (organization, city, state) Massachusetts General Hospital, Boston, MA Harvard School of Public Health, Boston, MA International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh KEY PERSONNEL. See instructions on Page 11. Use continuation pages as needed to provide the required information in the format shownbelow. Name Organization Role on Project Stephen B. Calderwood, MD Massachusetts General Hospital PI Jonathan Freeman, MD Harvard School of Public Health Co-Pi Edward T. Ryan, MD Massachusetts General Hospital Co-Pi David A. Sack, MD ICDDR,B Co-Pi Firdausi Qadri, Ph.D. ICDDR,B Co-Pi Syed M. Akramuzzaman, Ph.D. ICDDR,B Co-Pi PHS 398 (Rev. 4/98) Page 2 BB Number pages consecutively at the bottom throughout the application. Do not use suffixes such as 3a, 3b. NN Principal Investigator/Program Director (Lal^^s,¿t, middle): Calderwood. Stephen B. Type the name of the program director at the top of eacn printed page and each continuation page. (For type specifications, see instructions on page 6.) INSTITUTIONAL NATIONAL RESEARCH SERVICE AWARD (Substitute Page)