Mass Spec Resource

质谱仪资源- Stephen Calderwood， M.D.

NERCE: Mass Spec Resource - Stephen Calderwood, M.D. The LTQ XL is a fast scanning tandem mass spectrometer, capable of sequencing several peptides every second, allowing rapid characterization and quantification (using isotope labels) of proteins from microbes. The instrument also has several intermediate scan modes, allowing for neutral loss analysis of phosphate groups, as well as some medium full scan resolution modes for charge state assessment. The instrument has a higher duty cycle than the LTQ-FT, and a higher sensitivity for lower level peptides. Use of this instrument is prioritized for New England investigators working on NIAID Priority Pathogens, for which rapid identification of proteins and peptides will facilitate basic and applied science of relevant to the missions of NERCE, such as the identification of pathogen proteins that are potential targets for antimicrobial development. This resource is publicized to NERCE investigators via e-mail, the NERCE Website, and direct communication when appropriate.