TRAINING GRANT IN MUCOSAL IMMUNOLOGY AND EPIDEMIOLOGY

超出规定的空间。这笔培训补助金将支持题为“孟加拉国对霍乱弧菌感染的免疫反应”的国际传染病研究合作奖的研究和培训目标。在ICIDR奖中，我们建议在世界霍乱弧菌感染流行的地区调查那些对霍乱具有保护作用的粘膜免疫反应成分，并在细菌和宿主因素的多变量分析中将这些成分联系起来。我们有两位主要的外国合作者，孟加拉国达卡国际腹泻病研究中心（ICDDR，B）的一位高级免疫学家和一位高级流行病学家。ICDDR，B是国际公认的腹泻疾病研究机构。然而，该机构以及整个孟加拉国都迫切需要在现代免疫学和流行病学技术方面培训更多的科学家。在这项培训资助中，我们建议在孟加拉国确定两名博士级别的卫生专业人员，他们将来美国接受为期两年的培训。其中一名学员将专注于免疫学研究，并将在麻省总医院Pi的基础研究实验室学习两年，学习粘膜免疫学技术，如ELISA和抗体分泌细胞测定，杀弧菌抗体测量，并与相关动物模型一起工作。另一名受训者将专注于流行病学，在培训的第一年，将参加哈佛大学公共卫生学院传染病流行病学专业的流行病学硕士学位课程。在第二年，该个人将在孟加拉国实地进行流行病学研究，直接支持ICIDR赠款的研究和培训目标，并在孟加拉国和美国培训教员的联合监督下进行。该项目的候选人将首先由我们在孟加拉国ICDDR B的合作者确定，然后将与美国培训教师共同选择。我们决定的一个重要考虑因素是，这些人在完成培训后是否承诺返回孟加拉国工作，以及孟加拉国的一个机构（如ICDDR，B）是否承诺为他们提供一个职位。这笔培训赠款的目的是加强孟加拉国的科学和公共卫生基础设施，并支持ICIDR母奖的研究目标。网站性能 ======================================== 节结束 ===========================================

EXCEEDTHE SPACE PROVIDED. This training grant would support the research and training goals of the parent International Collaborations in Infectious Disease Research (ICIDR) Award, entitled "Immune responses to V. cholerae infection in Bangladesh". In the ICIDR Award, we proposed to investigate those components of the mucosal immune response that are protective against cholera in an area of the world endemic for V.cholerae infection, and to correlate these components in a multivariate analysis with bacterial and host factors. We have two major foreign collaborators, a senior immunologist and a senior epidemiologist at the International Centre for Diarrhoeal Disease Research in Dhaka, Bangladesh (ICDDR,B). The ICDDR,B is an internationally recognized facility for research in diarrheal diseases. However, there is a strong need at this institution, as well as in the country of Bangladesh overall, to train additional scientists in modern techniques of immunology and epidemiology. In this training grant, we propose to identify two doctoral level health professionals in Bangladesh, who will come to the US for training for a period of two years each. One trainee will focus on immunology research and will spend two years in the Pi's basic research laboratory at the Massachusetts General Hospital, learning mucosal immunological techniques such as ELISA and antibody-secreting cell assays, vibriocidal antibody measurements, and work with relevant animal models. The other trainee will focus on epidemiology and for the first year of training, will enroll in the Masters of Science in Epidemiology Degree program at the Harvard School of Public Health, in the Infectious Disease Epidemiology track. In the second year, this individual will do an epidemiological study in the field, in Bangladesh, in direct support of the research and training aims of the parent ICIDR grant, and under the joint supervision of the training faculty in both Bangladesh and the US. Candidates for this program will initially be identified by our collaborators at the ICDDR,B in Bangladesh and then will be jointly selected with the US training faculty. An important consideration for our decisions will be the commitment of the individuals to return to work in Bangladesh at the completion of training and the commitment of an institution in Bangladesh (such as the ICDDR,B) to give them a position. The intent of this training grant is to strengthen the scientific and public health infrastructure in Bangladesh and support the research aims of the parent ICIDR Award. PERFORMANCE SITE ========================================Section End===========================================