Neurocognitive Rehabilitation for Schizophrenia

精神分裂症的神经认知康复

• 批准号: 6926454
• 负责人: MATTHEW M KURTZ
• 金额: $ 14.41万
• 依托单位: HARTFORD HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6926454
• 关键词: behavior therapy; behavioral /social science research tag; clinical research; cognition; computer assisted instruction; computer human interaction; education evaluation /planning; functional ability; human subject; medical rehabilitation related tag; neuropsychology; patient oriented research; psychosocial rehabilitation; schizophrenia; statistics /biometry; training

DESCRIPTION (provided by applicant): We propose an integrated training and research plan designed to provide the PI with the experiences and skills necessary for transition to independence as a clinical research scientist with a focus on cognitive rehabilitation in schizophrenia. The centerpiece of the training plan is designed to provide the PI with skills in approaches to rehabilitation of neurocognitive deficits in schizophrenia and to help the PI conceptualize and test potential mechanisms of action of changes in neurocognitive function on more distal measures of psychosocial status. The program consists of three formal training modules that are designed to provide conceptual and practical skills in: (1) drill-and-practice restorative approaches to cognitive remediation; (2) how changes in neurocognitive skill may relate to simulated measures of functional skills, and (3) how change in neurocognitive function may relate to change in actual psychosocial status, e.g., community function and competitive vocational success. The last module will also include more general training in behavioral treatment trials research and biostatistics. Training will occur through interactions with the sponsor and through training visits to Cambridge University, the University of California at San Diego, the University of Southern California and the University of Maryland. While several recent studies have investigated the efficacy of cognitive remediation treatment for deficits in attention, memory and problem-solving in schizophrenia no study, to our knowledge, has: (1) compared the effects of extended, computer-assisted cognitive remediation training to a control condition consisting of equivalent duration and quality of clinician interaction and experience on a computer, and (2) investigated effects of remediation on a variety of neuropsychological and psychosocial outcome measures over time to help assess duration of effects, generalization and potential mechanisms of action. We propose a study of 105 patients with schizophrenia in outpatient rehabilitation who will be randomly assigned to either: (1) computer-assisted cognitive remediation training, (2) computer-literacy training, or (3) a non-computer-trained control group to help address these limitations.

描述（由申请人提供）：我们提出了一项综合培训和研究计划，旨在为PI提供过渡到独立作为临床研究科学家所需的经验和技能，重点是精神分裂症的认知康复。培训计划的核心旨在为PI提供精神分裂症神经认知缺陷康复方法的技能，并帮助PI概念化和测试神经认知功能变化对更远的心理社会状态测量的潜在作用机制。该计划包括三个正式的培训模块，旨在提供以下方面的概念和实践技能：（1）认知补救的训练和实践恢复方法;（2）神经认知技能的变化如何与功能技能的模拟测量相关，以及（3）神经认知功能的变化如何与实际心理社会状态的变化相关，例如，社区功能和竞争性职业成功。最后一个模块还将包括行为治疗试验研究和生物统计学方面的一般培训。培训将通过与申办者的互动以及对剑桥大学、加州大学圣地亚哥分校、南加州大学和马里兰州大学的培训访问进行。虽然最近的几项研究调查了认知补救治疗对精神分裂症患者注意力、记忆力和解决问题能力缺陷的疗效，但据我们所知，没有研究：（1）将扩展的计算机辅助认知补救训练的效果与由临床医生在计算机上的互动和经验的相同持续时间和质量组成的对照条件进行比较，以及（2）研究了补救措施对各种神经心理学和社会心理学结果的影响，以帮助评估影响的持续时间、泛化和潜在的作用机制。我们提出了一项研究，105例精神分裂症患者在门诊康复将随机分配到：（1）计算机辅助认知补救培训，（2）计算机素养培训，或（3）非计算机培训的对照组，以帮助解决这些限制。