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Comparing Cognitive Remediation Approaches for Schizophrenia

比较精神分裂症的认知治疗方法

基本信息

批准号：
9812554
负责人：
MATTHEW M KURTZ
金额：
$ 49.24万
依托单位：
WESLEYAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-08-01 至 2024-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9812554
关键词：
Address Attention Behavior Therapy Behavioral Bypass Caring Chronic Client Clinical Cognition Cognitive Cognitive deficits Cognitive remediation Communities Computer Assisted Control Groups Controlled Study Cost of Illness Diagnosis Distal Dose Elements Exercise Exhibits Foundations Goals Health Care Costs Impaired cognition Impairment Individual Insurance Intervention Investigational Therapies Label Language Lead Learning Life Link Literature Measures Mediating Medical Memory Mental disorders Meta-Analysis Methods Modeling Motor Skills Neurocognitive Deficit Neuronal Plasticity North America Onset of illness Outcome Outcome Measure Outcomes Research Participant Patient-Focused Outcomes Performance Pharmaceutical Preparations Prevalence Problem Solving Public Health Randomized Recommendation Research Resistance Schizoaffective Disorders Schizophrenia Sensory Severities Social Problems Social Security Societies Standardization Techniques Testing Time Training Unemployment Variant Wages Work atypical antipsychotic base cognitive capacity cognitive enhancement cognitive function cognitive skill cognitive training computer game computer program design follow-up functional outcomes improved novel prevent programs psychosocial psychosocial rehabilitation service utilization skills standard care therapy design treatment group

项目摘要

Abstract Evidence over the past 30 years has revealed that 70-80% of individuals with schizophrenia exhibit marked neurocognitive deficits on measures of attention, learning and memory, problem-solving, language and sensory-motor skill (e.g., Reichenberg & Harvey, 2007). Particular significance has been attached to these deficits as their severity has been linked to impaired community function, social problem-solving and progress in psychosocial rehabilitation programs (Green et al., 2000; Green et al., 2015). Cognitive remediation (CR) is a type of behavioral intervention that addresses cognitive deficits in schizophrenia by restoring lost cognitive skills or providing strategies for bypassing deficits through task practice. Meta-analyses (Wykes et al., 2011; McGurk et al., 2007) have revealed that cognitive remediation is a validated approach to improving cognitive function in schizophrenia, however a lack of precision regarding the active elements of the intervention have prevented its recommendation as a standard treatment for the illness (Dixon et al., 2010). The present three-year proposal seeks to identify cognitive training mechanisms that are most effective at improving cognitive function in schizophrenia by comparing two different systematic programs of CR with different foci: drill-and-practice exercises vs. compensatory strategies. Both programs have strong preliminary empirical support. One-hundred and thirty-five clients diagnosed with schizophrenia or schizoaffective disorder will be randomly assigned to one of three groups: a neuroplasticity-based, drill-and-practice program of computer-assisted cognitive training exercises designed to restore lost cognitive capacity; a manualized strategy training method for bypassing deficits in cognition, or a computer games control condition. Study measures, organized according to an experimental therapeutics approach, with targets distinguished from outcomes, will assess generalization of any observed training effects.

摘要