权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neurocognitive Rehabilitation for Schizophrenia

精神分裂症的神经认知康复

基本信息

批准号：
7609127
负责人：
MATTHEW M KURTZ
金额：
$ 15.57万
依托单位：
WESLEYAN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-04-01 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7609127
关键词：
Address Aftercare Attention Auditory Behavior Therapy Biometry California Classification Clinical Research Cognitive remediation Communities Computer Assisted Computer Literacy Computer software Computers Control Groups Distal Doctor of Philosophy Dose Elements Enrollment Exercise Hour Information Technology Internet Knowledge Mails Maryland Measures Memory Neurocognitive Neurocognitive Deficit Outcome Measure Outpatients Participant Patients Performance Pharmaceutical Preparations Problem Solving Process Randomized Reaction Time Rehabilitation therapy Relative (related person)Research Research Personnel Research Training Schizophrenia Scientist Simulate Symptoms Testing Time Training Training Programs Universities Visit Visual atypical antipsychotic base cognitive rehabilitation computerized design experience follow-up neuropsychological programs psychosocial remediation skills skills training success time interval treatment trial

项目摘要

DESCRIPTION (provided by applicant): We propose an integrated training and research plan designed to provide the PI with the experiences and skills necessary for transition to independence as a clinical research scientist with a focus on cognitive rehabilitation in schizophrenia. The centerpiece of the training plan is designed to provide the PI with skills in approaches to rehabilitation of neurocognitive deficits in schizophrenia and to help the PI conceptualize and test potential mechanisms of action of changes in neurocognitive function on more distal measures of psychosocial status. The program consists of three formal training modules that are designed to provide conceptual and practical skills in: (1) drill-and-practice restorative approaches to cognitive remediation; (2) how changes in neurocognitive skill may relate to simulated measures of functional skills, and (3) how change in neurocognitive function may relate to change in actual psychosocial status, e.g., community function and competitive vocational success. The last module will also include more general training in behavioral treatment trials research and biostatistics. Training will occur through interactions with the sponsor and through training visits to Cambridge University, the University of California at San Diego, the University of Southern California and the University of Maryland. While several recent studies have investigated the efficacy of cognitive remediation treatment for deficits in attention, memory and problem-solving in schizophrenia no study, to our knowledge, has: (1) compared the effects of extended, computer-assisted cognitive remediation training to a control condition consisting of equivalent duration and quality of clinician interaction and experience on a computer, and (2) investigated effects of remediation on a variety of neuropsychological and psychosocial outcome measures over time to help assess duration of effects, generalization and potential mechanisms of action. We propose a study of 105 patients with schizophrenia in outpatient rehabilitation who will be randomly assigned to either: (1) computer-assisted cognitive remediation training, (2) computer-literacy training, or (3) a non-computer-trained control group to help address these limitations.

描述（由申请人提供）：我们提出了一个综合培训和研究计划，旨在为PI提供必要的经验和技能，以过渡到独立的临床研究科学家，专注于精神分裂症的认知康复。培训计划的核心是为精神分裂症患者提供神经认知功能障碍康复方法的技能，并帮助精神分裂症患者概念化和测试神经认知功能变化在更远的社会心理状态测量中的潜在作用机制。该计划包括三个正式的培训模块，旨在提供概念和实践技能：(1)认知补救的操练和实践恢复方法；(2)神经认知技能的变化如何与功能技能的模拟测量相关；(3)神经认知功能的变化如何与实际社会心理状态的变化相关，例如社区功能和竞争性职业成功。最后一个模块还将包括行为治疗试验研究和生物统计学方面的更多一般培训。培训将通过与赞助商的互动以及对剑桥大学、加州大学圣地亚哥分校、南加州大学和马里兰大学的培训访问进行。虽然最近有几项研究调查了认知补救治疗对精神分裂症患者注意力、记忆力和解决问题能力缺陷的疗效，但据我们所知，没有一项研究：(1)将延长的、计算机辅助的认知修复训练的效果与由临床医生在计算机上的互动和体验的同等时间和质量组成的对照条件进行比较；(2)随着时间的推移，研究了修复对各种神经心理和社会心理结果的影响，以帮助评估效果的持续时间、泛化和潜在的作用机制。我们建议对105名精神分裂症门诊康复患者进行研究，他们将被随机分配到：(1)计算机辅助认知修复训练，(2)计算机素养训练，或(3)非计算机训练对照组，以帮助解决这些局限性。