novel technological solutions to perform wearable broadband spectroscopy

在传统的神经成像(如功能磁共振成像)不可能的情况下，如重症监护或社区，NIRS是一种重要的脑功能成像工具。我们的实验室开发了宽带光谱技术，利用近红外光谱进行新陈代谢监测。这在脑损伤、自闭症和痴呆症方面有独特的应用。为了促进这些工具进入临床，需要开发覆盖整个大脑的非侵入性和可穿戴的设备，以便在最需要的地方进行代谢成像。在我的项目中，我将测试和开发执行可穿戴宽带光谱的新技术解决方案。这些解决方案可以是内部开发的解决方案，也可以是我们实验室内的现有设备，也可以是与行业合作的解决方案。在成功展示可穿戴式单通道头上光谱的基础上，我将致力于开发一种用于全头代谢成像的多通道系统。该项目将包括创建新的计算方法，以及实验光学，以实现大脑代谢功能的漫反射光学成像。这些设备将通过模拟生物光学特性的测试对象和健康的人类志愿者进行验证。该项目是与物理系的Sarah Bohndiek博士(VISIONLab)合作完成的。该系统最终将部署在阿登布鲁克医院，与精神病学系约翰·奥布莱恩教授一起研究痴呆症的光学代谢生物标记物。

NIRS is a prominent tool for functional brain imaging in situations where traditional neuroimaging (e.g. fMRI) isn't possible, such as intensive care or in the community. Our lab develops broadband spectroscopy techniques to perform metabolic monitoring with NIRS. This has unique applications in brain injury, autism and dementia. To facilitate the translation of these tools into the clinic, devices need to be developed to cover the whole brain that are non-invasive and wearable, to perform metabolic imaging where is it most needed. In my project, I will test and develop novel technological solutions to perform wearable broadband spectroscopy. These solutions could range from those developed in-house, existing equipment within our laboratories, or with industry. On successful demonstration of wearable single-channel on-head spectroscopy, I will pursue the development of a multichannel system for whole-head metabolic imaging. This project will involve creating new computational methods alongside experimental optics to achieve diffuse optical imaging of cerebral metabolic function. These devices will be validated with test objects which mimic biological optical properties and on healthy human volunteers. This project is in collaboration with Dr Sarah Bohndiek (VISIONLab) in the Department of Physics. This system will ultimately be deployed in the Addenbrooke's Hospital to investigate optical metabolic biomarkers of dementia with Prof John O'Brien, Department of Psychiatry.