Nore1 Class Effectors in Ras Mediated Transformation

Ras癌基因介导多种促进致瘤转化的生物学效应。然而，Ras的活化形式也具有数量惊人的反转化方面。它们可以诱导衰老、细胞周期阻滞甚至凋亡死亡。这些抗弹性体效应背后的机制仍然知之甚少。我们已经确定了一系列新的Ras效应物，它们似乎介导了Ras的一些抗肿瘤活性。尤其是细胞凋亡。我们现在已经确定，这个家族中至少有三个成员表现出Ras效应子的所有经典特征，同时也表现出肿瘤抑制因子的特性。即，介导细胞生长和转化的抑制，并在肿瘤发生过程中经常被表观遗传机制下调。我们现在有初步的数据表明，这个家族的另外两个成员也有类似的特性。因此，我们已经鉴定并部分表征了一类新的Ras激活的肿瘤抑制因子。

The Ras oncogene mediates a variety of biological effects which promote tumorigenic transformation. However, activated forms of Ras also have a surprising number anti-transformation aspects. They can induce senesence, cell cycle arrest and even death by apoptosis. The mechanisms behind these anti-neolastic effects remain poorly understood. We have identified a family of novel Ras effectors which appear to mediate some of the anti-neoplastic activities of Ras. especialy apoptosis. We have now determined that at least three members of this family exhibit all the classic hall marks of Ras effectors yet also demonstrate the properties of tumor suppressors. Namely, the mediate inhibition of cell growth and transformation and are frequently down-regulated by epigenetic mechanisms during tumor development. We now have preliminary data that two other members of this family have similar properties. Thus, we have identified and partially characterized a novel class of Ras activated tumor suppressor.