Cancer and Leukemia Group B

描述（由申请人提供）：本申请是北卡罗来纳大学教堂山分校（UNC-CH）及其附属机构提交的CALGB机构资助提交的第二次竞争性更新。联合国军司令部自1986年以来一直是CALGB的成员。我们的累积病例数维持在大约40例治疗病例（包括6-10例少数病例/年）加上伴随研究。我们还拥有一个附属网络，负责另外60-90个应计项目/年，同时保持良好的数据质量控制。此外，我们的机构现在在乳腺癌、癌症预防和控制、GI、淋巴瘤、分子病理学、放射肿瘤学等领域拥有广泛的领导参与，并且是北卡罗来纳大学少数民族倡议项目和弗吉尼亚州立大学少数民族CCOP的研究基地。此外，我们在集团内的领导工作也继续扩大。我们现在拥有1名委员会主席，5名委员会副主席，7名委员会或工作组核心或联络成员，8名形式委员会成员，1名执行委员会成员，2名董事会成员，5名行政委员会成员和7名议定书主要调查员。在过去的五年中，UNC及其附属机构的成员在CALGB的各种科学，行政和领导委员会中担任了56个职位。北卡罗来纳大学附属医院的其他教职员工将扩大我们在乳腺、外科、GU、GI、淋巴瘤和PET委员会（F. Detterbeck、M. Graham、C. Sartor、L. Carey、J. Mohler、R. Pruthi、B. O'Neil、R. Orlowski、P. Watkins和C. Dees）的承诺和团队领导地位。因此，我们认为，这一应用反映了UNC-CH调查员在领导，科学和服务方面为集团提供的日益增长和至关重要的贡献，以及我们通过附属成员继续努力增加应计收益，同时保持严格控制质量数据提交。我们谨指出，这一申请既表明了该机构目前对该集团的价值，也表明了联合国军司令部及其附属机构的成员将在今后五年内继续向CALGB提供的贡献。

DESCRIPTION (provided by applicant): This application represents the second competitive renewal of the CALGB institutional grant submission from the University of North Carolina at Chapel Hill (UNC-CH) and its affiliates. UNC-CH has been a member of CALGB since 1986. Our accrual has been maintained at approximately 40 treatment cases (including 6-10 minority accruals/year) plus companion studies. We also maintain an affiliate network responsible for another 60-90 accruals/year while maintaining excellent data quality control. Moreover, our institution now has broad leadership participation in the Group in Breast, Cancer Prevention and Control, GI, Lymphoma, Molecular Pathology, Radiation Oncology, and is the research base for a UNC based Minority Initiative Program and a VCU based Minority CCOP. Moreover, our leadership efforts in the Group have also continued to expand. We now enjoy the distinction of having one committee chair, five committee vice-chairs, seven committee or working group core or liaison members, eight modality committee members, one Executive Committee member, two members of the Board of Directors, five administrative committee members and seven protocol principal investigators. Members from UNC and its affiliates have held 56 positions on various scientific, administrative, and leadership committees of CALGB during the past 5 years. Additional faculty at UNC-CH will expand our commitment and Group leadership in the Breast, Surgery, GU, GI, Lymphoma and PET committees (F. Detterbeck, M. Graham, C. Sartor, L. Carey, J. Mohler, R. Pruthi, B. O'Neil, R. Orlowski, P. Watkins, and C. Dees). We therefore believe that this application reflects the growing and crucial contribution that UNC-CH investigators provide to the Group in leadership, science and service as well as our continued efforts to increase accrual through affiliate members while maintaining rigorous control of quality data submission. We respectfully submit that this application demonstrates both the current value of this institution to the Group and the contributions that: the membership of UNC-CH and its affiliates will continue to provide CALGB over the next five years.