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PHARMACODYNAMIC MODELING OF ORAL ETOPOSIDE IN RELAPSED NON HODGKINS

PHARMACODYNAMIC MODELING OF ORAL ETOPOSIDE IN RELAPSED NON HODGKINS
复发性非霍奇金病患者口服依托泊苷的药效学模型
批准号：
6297218
负责人：
Thomas C. Shea
金额：
$0.02万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
项目状态：
已结题
起止时间：
1998-12-01 至 1999-11-30
来源：
https://reporter.nih.gov/project-details/6297218
关键词：
age difference clinical research drug screening /evaluation etoposide human subject human therapy evaluation neoplasm /cancer chemotherapy nonHodgkin's lymphoma oral administration pharmacokinetics

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中文摘要
翻译
研究目的：本研究的目的是：(1)监测依托泊苷谷底水平，确定依托泊苷浓度与肿瘤反应、毒性之间的药效学关系，以及依托泊苷浓度与年龄之间的药动学关系；(2)评估先前治疗过的非霍奇金淋巴瘤IWF A-H对每日口服依托泊苷的反应率和反应持续时间；(3)评估口服依托泊苷对复发性NHL患者的毒性。
英文摘要
PURPOSE OF STUDY: The objectives of this study are: (1) to monitor etoposide trough levels and determine the pharmacodynamic relationships benween etoposide concentration, tumor response, and toxicity, as well as the pharmacokinetic relationship between etoposide concentration and age; (2) to evaluate the response rate and response duration of previously treated non-Hodgkin's lymphoma IWF A-H to daily oral etoposide; (3) to assess the toxicity of oral etoposide in patients with relapsed NHL.
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CORE--PROTOCOL REVIEW AND MONITORING SYSTEM
FILGRASTIM ALONE OR IN COMBINATION W/ R METHUSCF IN BREAST CANCER
PHARMACODYNAMIC MODELING OF ORAL ETOPOSIDE IN RELAPSED NON HODGKINS
PHARMACODYNAMIC MODELING OF ORAL ETOPOSIDE IN RELAPSED NON HODGKINS
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