Comorbidity of Mental Disorders and Pain

描述（由申请人提供）：本申请NIMH高级科学家奖（K05）的重点是更好地理解与精神障碍和复杂疼痛问题共病相关的生物心理社会机制。该方案致力于实现“ 2010年健康人群：了解和改善健康”的目标1，即提高与健康有关的生活质量，特别关注共病性精神健康障碍和最普遍和最昂贵的疼痛形式之一（慢性背痛）。我们还将重点关注成功的转化干预研究，这是NIH的重中之重。我正在进行的生物心理社会研究项目调查精神障碍和疼痛的共病，包括四个相互关联的组成部分：早期干预转化研究；成本效益转化研究；基础神经基质模型相关研究；和功能磁共振成像研究。为此，我们将在未来五年及以后开展三个独立的研究项目：预防共病性精神障碍和身体健康残疾；精神疾病与颞下颌疾病（TMD）共病的评估与早期干预研究还有一项对军人群体的共病性精神障碍和肌肉骨骼疼痛干预的随机试验。所有这些项目都将侧重于早期发现，以预防这些慢性疾病的发展，这是公共卫生服务“2000年健康人”报告中确认的一个高度优先的研究领域。我目前和未来的许多研究项目也将评估疼痛和压力之间相互作用的潜在启发式理论（疼痛的神经基质模型）。此外，我们计划在未来的研究项目中使用新的功能磁共振成像技术，以更全面地了解共病精神障碍和疼痛的生物心理社会机制。这个奖项将使我能够保持NIMH连续两届K02奖的势头和临床研究进展。

DESCRIPTION (provided by applicant): This request for an NIMH Senior Scientist Award (K05) focuses on better understanding the biopsychosocial mechanisms associated with the comorbidity of mental disorders and complex pain problems. The program addresses Goal 1 of "Healthy People 2010: Understanding and Improving Health"--to improve health-related quality of life, with a special focus on comorbid mental health disorders and one of the most prevalent and costly forms of pain (chronic back pain). We will also focus on successful translational intervention research, which is a high priority of NIH. My ongoing biopsychosocial research program investigating the comorbidity of mental disorders and pain contains four inter-related components: early intervention translational research; cost-effectiveness translational research; underlying neuromatrix model-related research; and fMRI research. To that end, we will pursue three separate research projects over the next five years and beyond: preventing comorbid mental disorders and physical health disability; an evaluation and early intervention study of comorbid psychiatric and temporomandibular (TMD) disorders; and a randomized trial of comorbid mental disorders and musculoskeletal pain intervention in a military population. All of these projects will focus on early detection to prevent the development of such chronic disorders, recognized as a high priority research area in the PHS Report of "Healthy People 2000." Many of my current and future research projects will also evaluate a potentially heuristic theory of the interaction between pain and stress (the neuromatrix model of pain). In addition, we plan to use new fMRI technology in our future research projects to develop a more comprehensive understanding of biopsychosocial mechanisms of comorbid mental disorders and pain. This Award will enable me to maintain the momentum and clinical research advances of two previous consecutive K02 awards from NIMH.