Comorbidity of Mental Disorders and Pain

描述(由申请人提供)：本申请为NIMH高级科学家奖(K05)，重点是更好地了解与精神障碍和复杂疼痛问题共病相关的生物-心理-社会机制。该计划致力于“2010年健康人：了解和改善健康”的目标1--提高与健康有关的生活质量，特别关注精神健康障碍和最普遍、最昂贵的疼痛形式之一(慢性背痛)。我们还将专注于成功的翻译干预研究，这是美国国立卫生研究院的高度优先事项。我正在进行的生物心理社会研究计划调查精神障碍和疼痛的共病，包括四个相互关联的部分：早期干预转换研究；成本效益转换研究；潜在的神经矩阵模型相关研究；以及功能磁共振研究。为此，我们将在未来五年及以后开展三个独立的研究项目：预防共病精神障碍和身体健康残疾；对共病精神障碍和颞颌(TMD)障碍的评估和早期干预研究；以及在军事人群中进行共病精神障碍和肌肉骨骼疼痛干预的随机试验。所有这些项目都将侧重于及早发现，以防止此类慢性疾病的发展，这是小灵通2000年《健康人》报告中确认的一个高度优先的研究领域。我目前和未来的许多研究项目还将评估一种潜在的关于疼痛和压力之间相互作用的启发式理论(疼痛的神经矩阵模型)。此外，我们计划在未来的研究项目中使用新的功能磁共振成像技术，以更全面地了解并存的精神障碍和疼痛的生物、心理和社会机制。这一奖项将使我能够保持NIMH连续两次获得K02奖项的势头和临床研究进展。

DESCRIPTION (provided by applicant): This request for an NIMH Senior Scientist Award (K05) focuses on better understanding the biopsychosocial mechanisms associated with the comorbidity of mental disorders and complex pain problems. The program addresses Goal 1 of "Healthy People 2010: Understanding and Improving Health"--to improve health-related quality of life, with a special focus on comorbid mental health disorders and one of the most prevalent and costly forms of pain (chronic back pain). We will also focus on successful translational intervention research, which is a high priority of NIH. My ongoing biopsychosocial research program investigating the comorbidity of mental disorders and pain contains four inter-related components: early intervention translational research; cost-effectiveness translational research; underlying neuromatrix model-related research; and fMRI research. To that end, we will pursue three separate research projects over the next five years and beyond: preventing comorbid mental disorders and physical health disability; an evaluation and early intervention study of comorbid psychiatric and temporomandibular (TMD) disorders; and a randomized trial of comorbid mental disorders and musculoskeletal pain intervention in a military population. All of these projects will focus on early detection to prevent the development of such chronic disorders, recognized as a high priority research area in the PHS Report of "Healthy People 2000." Many of my current and future research projects will also evaluate a potentially heuristic theory of the interaction between pain and stress (the neuromatrix model of pain). In addition, we plan to use new fMRI technology in our future research projects to develop a more comprehensive understanding of biopsychosocial mechanisms of comorbid mental disorders and pain. This Award will enable me to maintain the momentum and clinical research advances of two previous consecutive K02 awards from NIMH.