Comorbidity of Mental Disorders and Pain

精神障碍和疼痛的合并症

• 批准号: 7276652
• 负责人: ROBERT Joseph GATCHEL
• 金额: $ 24.67万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-09-01 至 2009-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7276652
• 关键词: Address; Area; Award; Back Pain; Chronic Disease; Clinical Research; Comorbidity; Complex; Development; Disability Evaluation; Early Diagnosis; Early Intervention; Functional Magnetic Resonance Imaging; Future; Goals; Health; Healthy People 2000; Healthy People 2010; Independent Scientist Award; Intervention; Intervention Studies; Mental Health; Mental disorders; Military Personnel; Modeling; Musculoskeletal Pain; National Institute of Mental Health; Pain; Pain Disorder; Population; Randomized Controlled Clinical Trials; Reporting; Research; Research Priority; Research Project Grants; Senior Scientist Award; Stress; Technology; Temporomandibular Joint Disorders; Translational Research; United States National Institutes of Health; biopsychosocial; chronic pain; cost effectiveness; health related quality of life; heuristics; improved; prevent; programs; theories

DESCRIPTION (provided by applicant): This request for an NIMH Senior Scientist Award (K05) focuses on better understanding the biopsychosocial mechanisms associated with the comorbidity of mental disorders and complex pain problems. The program addresses Goal 1 of "Healthy People 2010: Understanding and Improving Health"--to improve health-related quality of life, with a special focus on comorbid mental health disorders and one of the most prevalent and costly forms of pain (chronic back pain). We will also focus on successful translational intervention research, which is a high priority of NIH. My ongoing biopsychosocial research program investigating the comorbidity of mental disorders and pain contains four inter-related components: early intervention translational research; cost-effectiveness translational research; underlying neuromatrix model-related research; and fMRI research. To that end, we will pursue three separate research projects over the next five years and beyond: preventing comorbid mental disorders and physical health disability; an evaluation and early intervention study of comorbid psychiatric and temporomandibular (TMD) disorders; and a randomized trial of comorbid mental disorders and musculoskeletal pain intervention in a military population. All of these projects will focus on early detection to prevent the development of such chronic disorders, recognized as a high priority research area in the PHS Report of "Healthy People 2000." Many of my current and future research projects will also evaluate a potentially heuristic theory of the interaction between pain and stress (the neuromatrix model of pain). In addition, we plan to use new fMRI technology in our future research projects to develop a more comprehensive understanding of biopsychosocial mechanisms of comorbid mental disorders and pain. This Award will enable me to maintain the momentum and clinical research advances of two previous consecutive K02 awards from NIMH.

描述（由申请人提供）：NIMH高级科学家奖（K 05）的申请重点是更好地理解与精神障碍和复杂疼痛问题合并症相关的生物心理社会机制。该方案涉及“2010年健康人民：了解和改善健康”的目标1-改善与健康有关的生活质量，特别关注共病精神健康障碍和最普遍和代价最高的疼痛形式之一（慢性背痛）。我们还将专注于成功的转化干预研究，这是NIH的高度优先事项。我正在进行的生物心理社会研究计划调查精神障碍和疼痛的共病包括四个相互关联的组成部分：早期干预转化研究;成本效益转化研究;基础神经基质模型相关研究;和功能磁共振成像研究。为此，我们将在未来五年及以后开展三个独立的研究项目：预防共病精神障碍和身体健康残疾;共病精神和颞下颌关节（TMD）障碍的评估和早期干预研究;以及在军事人群中进行共病精神障碍和肌肉骨骼疼痛干预的随机试验。所有这些项目都将侧重于早期发现，以防止这种慢性疾病的发展，这是公共卫生服务局“2000年健康人”报告中确认的一个高度优先研究领域。“我目前和未来的许多研究项目也将评估疼痛和压力之间相互作用的潜在启发性理论（疼痛的神经基质模型）。此外，我们计划在未来的研究项目中使用新的功能磁共振成像技术，以更全面地了解共病精神障碍和疼痛的生物心理社会机制。该奖项将使我能够保持NIMH之前连续两次获得K 02奖项的势头和临床研究进展。