An Implementation and Biobehavioral Study of TMJMD

TMJMD 的实施和生物行为研究

• 批准号: 7662332
• 负责人: ROBERT Joseph GATCHEL
• 金额: $ 82.99万
• 依托单位: UNIVERSITY OF TEXAS ARLINGTON
• 依托单位国家: 美国
• 财政年份: 1994
• 资助国家: 美国
• 起止时间: 1994-06-01 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7662332
• 关键词: Academy; Acute; Address; Adrenal Glands; Adult; Aftercare; Algorithms; American; Attention; Behavior; Behavior Therapy; Behavioral Sciences; Biological; Chronic; Chronic Disease; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Communities; Complex; Control Groups; Cost Savings; Costs and Benefits; Data; Dental; Dental Care; Dental Clinics; Dental General Practice; Dentistry; Development; Diabetes Mellitus; Diagnosis; Dimensions; Direct Costs; Disease; Early Diagnosis; Early treatment; Educational workshop; Effectiveness; Environment; Equation; Evaluation; Evidence based program; Evidence based treatment; Evolution; Facilities and Administrative Costs; Funding; Future; General Population; Goals; Grant; Health Care Costs; Health Personnel; Human; Hydrocortisone; Hypothalamic structure; Individual Differences; Intervention; Lead; Literature; Managed Care; Mastication; Measures; Medical; Mental Health; Methodology; Modeling; Myopathy; Nature; Obesity; Orofacial Pain; Outcome; Outcome Study; Pain; Pathway interactions; Patients; Pattern; Performance; Pituitary Gland; Population; Prevalence; Private Practice; Process; Public Health; Randomized; Randomized Controlled Trials; Recruitment Activity; Relative (related person); Reporting; Research; Research Personnel; Risk; Risk Factors; Sampling; Science; Scientific Advances and Accomplishments; Screening procedure; Seminal; Series; Source; Specific qualifier value; Staging; Surveys; Symptoms; System; Technology; Temporomandibular Joint; Therapeutic; Translating; Treatment Cost; Treatment Efficacy; Treatment Protocols; Unemployment; United States; Visit; Woman; base; biobehavior; biopsychosocial; brain behavior; chronic pain; cohort; college; community setting; cost; cost effectiveness; disability; economic cost; experience; follow-up; group intervention; high risk; hypothalamic-pituitary-adrenal axis; intervention program; men; new technology; post intervention; prevent; psychologic; psychosocial; response; social; treatment program; trend

DESCRIPTION (provided by applicant): With the great economic costs and traditionally poor outcomes among chronic temporomandibular joint and muscle disorder (TMJMD) patients, it has become important to treat patients in the acute state, in order to prevent these more chronic disability problems. This has been the goal of two past funded grant projects. Results of the initial project isolated risk factors that successfully predicted the development of chronicity, with a 91% accuracy rate. A statistical algorithm was developed which was used in the second project to screen out "high-risk" patients. These patients were then randomly assigned an early intervention or non-intervention group. One-year follow-up evaluations documented the treatment efficacy and cost effectiveness of early intervention. These results have major implications for effective early intervention and significant health-care cost savings for this prevalent pain and disability problem. For the present proposed project, we plan to implement this treatment program in order to evaluate its effectiveness in more community-based dental practices. This is in response to NIH's request for the implementation of evidence-based treatment approaches, developed in controlled clinical settings, to the "real world" of diverse practices in the community. Acute TMJMD patients will be recruited from two community clinics. Based upon our "risk" screening algorithm, high-risk patients will be randomly assigned to one of two groups (n=225/group): an early biobehavioral intervention or an attention-control group. It is hypothesized that the attention control "high-risk" patients will display more chronic TMJMD problems, relative to the "high-risk" early intervention patients, at one-year follow-up. Another aim of the project is to evaluate the potential utility of new technologies that will lead to even greater precision in detecting individual differences among TMJMD patients. Measures evaluated include chewing performance, cortisol levels, and other biopsychosocial outcomes. This represents the next step in comprehensively understanding brain-behavior patterns in TMJMD. Also, structural equation modeling methodology will be used. Such a multi-level, multi-systems approach has not been applied to better understand the biopsychosocial underpinnings of TMJMD. Results from this component of the project will greatly aid in stimulating future research leading to the better understanding of TMJMD, as well as better tailoring of prescribed treatment regimens. Project Narrative: Temporomandibular joint and muscle disorder (TMJMD) is a highly prevalent and costly public health problem in the United States, especially when it becomes chronic in nature. This study will further evaluate the treatment- and cost-effectiveness of an early biobehavioral intervention program for preventing chronic TMJMD. Moreover, this evidence-based program will be implemented in actual community-based dental practices to make it more accessible to the general population.

描述（由申请人提供）：由于慢性颞下颌关节和肌肉疾病（TMJMD）患者的经济成本高，传统上预后差，因此在急性状态下治疗患者变得非常重要，以防止这些更慢性的残疾问题。这是过去两个资助项目的目标。最初项目的结果分离出了成功预测慢性发展的风险因素，准确率为91%。开发了一种统计算法，在第二个项目中用于筛选“高风险”患者。然后将这些患者随机分为早期干预组和非干预组。一年的随访评估记录了早期干预的治疗效果和成本效益。这些结果对有效的早期干预和显著节省这一普遍疼痛和残疾问题的医疗保健费用具有重要意义。对于目前提出的项目，我们计划实施这一治疗方案，以评估其在更多社区牙科诊所的有效性。这是对美国国立卫生研究院要求实施循证治疗方法的回应，这些方法是在受控的临床环境中开发的，以适应社区中各种实践的“现实世界”。急性TMJMD患者将从两个社区诊所招募。根据我们的“风险”筛选算法，高危患者将被随机分配到两组（n=225/组）中的一组：早期生物行为干预组或注意力控制组。假设在一年的随访中，注意控制“高风险”患者相对于“高风险”早期干预患者会出现更多的慢性TMJMD问题。该项目的另一个目的是评估新技术的潜在效用，这些新技术将导致更精确地检测TMJMD患者之间的个体差异。评估的措施包括咀嚼性能、皮质醇水平和其他生物心理社会结果。这代表了全面了解TMJMD大脑行为模式的下一步。此外，结构方程建模方法将被使用。这种多层次、多系统的方法尚未被应用于更好地理解TMJMD的生物、心理和社会基础。该项目的这一组成部分的结果将极大地有助于刺激未来的研究，从而更好地了解TMJMD，以及更好地定制处方治疗方案。项目描述：颞下颌关节和肌肉紊乱（TMJMD）在美国是一个非常普遍和昂贵的公共卫生问题，特别是当它成为慢性疾病时。本研究将进一步评估早期生物行为干预计划预防慢性颞下颌关节关节病的治疗效果和成本效益。此外，这个以证据为基础的项目将在实际的社区牙科实践中实施，使其更容易为普通人群所接受。