Continuing Retrospective and Prospective Studies Based on Detailed Clinical Obser

该项目由49个子项目组成，每个子项目包含一个单独的问题，要问我们的综合计算机临床数据存储和检索系统。我们收集了1968年以来在明尼苏达大学进行的5700多例肾脏移植手术的数据，以及1984年以来3600例移植患者的非常全面的信息。多种细节（术前危险因素、组织分型、移植入院和手术、供体信息、移植后再入院、排斥反应、活检、感染和其他并发症、生活质量、康复）都是可用的。新移植物进入前瞻性；此外，我们正在将1984年之前移植的患者添加到该数据库中。计划进行两种类型的研究——回顾性和前瞻性。在其中一些子项目中，已经完成了数据收集并计划进行分析。另一些则是长期随访

This project consists of 49 subprojects, each of which comprises a separate question to be asked of our comprehensive computerized clinical data storage and retrieval systems. We have collected data on more than 5,700 kidney transplants performed at the University of Minnesota since 1968, and very comprehensive information on 3,600 patients transplanted since 1984. Multiple details (preoperative risk factors; tissue typing; the transplant admission and surgery; donor information; post transplant readmissions, rejections, biopsies, infections, and other complications; quality of life, rehabilitation) are available. New transplantas are entered prospectively; in addition, we are adding patients transplanted prior to 1984 into this database. Two types of studies are planned--retrospective and prospective. In some of these subprojects, data collection has been completed and analysis is planned. In others, long-term follow-up is required. Our computer database permits us to study transplant risk factors to an extent that has not previously been possible. The computer allows analysis of mini-series of subgroups of patients and/or multivariate analysis of the importance of risk factors. Among the most important of the subprojects are: A. Impact of "hypercoagulability" on graft loss; D. Is C4d staining helpful in interpreting renal allograft biopsies?; G. Outcome in relation to recipient risk factors; J. How can outcome be maximized for recipients with failing grafts?; R. Is long-term outcome improving for current recipients?; T. Skin cancer; U. Defining slow graft function; W. Relationship between bone disease and cardiovascular disease; X. Ongoing studies on nondirected donation; II. Risk factors in diabetic and non-diabetic recipients.