Improving the outcome of organ transplantation by analysis of chemokine modifications in ischaemia reperfusion injury

通过分析缺血再灌注损伤中趋化因子的修饰来改善器官移植的效果

• 批准号: 2599192
• 金额: --
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2021
• 资助国家: 英国
• 起止时间: 2021 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2599192
• 关键词: Improving; outcome; organ; transplantation; analysis

"Ischaemia reperfusion injury (IRI) is associated with serious clinical manifestations including myocardial infarction, stroke and transplant rejection. Despite advances in understanding IRI pathogenesis, the translation of findings into clinically applicable therapies has been disappointing.Oxidative stress associated with IRI induces expression of inflammatory chemokines as well as their posttranslational modifications. This affects chemokine interactions with G protein-coupled receptors and glycosaminoglycans, biological potency of chemokines, or even generates functional antagonists. Therefore, assessing the structural and functional consequences of post-translational modifications of chemokines is crucial to develop new therapies."

“缺血再灌注损伤（IRI）与严重的临床表现有关，包括心肌梗死、中风和移植排斥反应。尽管在理解IRI发病机制方面取得了进展，但将这些发现转化为临床可应用的治疗方法却令人失望。与IRI相关的氧化应激诱导炎性趋化因子的表达及其翻译后修饰。这会影响趋化因子与G蛋白偶联受体和糖胺聚糖的相互作用、趋化因子的生物学效价，甚至产生功能性拮抗剂。因此，评估趋化因子的翻译后修饰的结构和功能后果对于开发新的疗法至关重要。"